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myo-Inositol trispyrophosphate hexasodium

(Synonyms: ITPP hexasodium)

目录号: PL08251 纯度: ≥98.0%

myo-Inositol trispyrophosphate (ITPP) hexasodium 是血红蛋白 (haemoglobin) 调节剂，是一种变构效应物，可降低血红蛋白的氧结合亲和力并促进红细胞释放氧。myo-Inositol trispyrophosphatehexasodium 可以逆转缺氧，控制肿瘤生长并改善化疗反应。

CAS No. :23103-35-7

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PL08251-100mg	100mg	询价	询价

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中文名称	myo-Inositol trispyrophosphate hexasodium
中文别名	环己六醇环-1,2:3,4:5,6-三(P,P''-二氢二磷酸酯)六钠盐;环己六醇环-1,2:3,4:5,6-三(P,P'-二氢二磷酸酯)六钠盐;环己六醇环-1,2:3,4:5,6-三(P,P-二氢二磷酸酯)六钠盐;ITPP六钠盐
英文名称	myo-Inositol trispyrophosphate hexasodium
英文别名	myo-Inositol Trispyrophosphate Hexasodium Salt;ITPP;ITTP Hexasodium Salt;ITPP SODIUM SALT;myo-Inositol trispyrophosphate hexasodium
Cas No.	23103-35-7
分子式	C₆H₆O₂₁P₆-₆^.₆[Na+]
分子量	737.88
包装储存	-20°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
详情描述	myo-Inositol trispyrophosphate (ITPP) hexasodium 是血红蛋白 (haemoglobin) 调节剂，是一种变构效应物，可降低血红蛋白的氧结合亲和力并促进红细胞释放氧。myo-Inositol trispyrophosphatehexasodium 可以逆转缺氧，控制肿瘤生长并改善化疗反应。

产品详情	myo-Inositol trispyrophosphate (ITPP) hexasodium 是血红蛋白 (haemoglobin) 调节剂，是一种变构效应物，可降低血红蛋白的氧结合亲和力并促进红细胞释放氧。myo-Inositol trispyrophosphatehexasodium 可以逆转缺氧，控制肿瘤生长并改善化疗反应。
生物活性	myo-Inositol trispyrophosphate (ITPP) hexasodium, a modifier of haemoglobin, is an allosteric effector that reduces the oxygen‐binding affinity of haemoglobin and facilitates the release of oxygen by red blood cells. myo-Inositol trispyrophosphate can reverse hypoxia, control tumor growth and improve chemotherapy response.
性状	Solid
体外研究(In Vitro)	myo-Inositol trispyrophosphate hexasodium (10 mmol/L; 2 hours) significantly inhibits OCR in all six cell lines (FSaII, SiHa, MDA‐MB‐231, NT2, 9L‐glioma and rhabdomyosarcoma) . has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	myo-Inositol trispyrophosphate hexasodium (2 g/kg weekly; IP; 7weeks) sustains its significant effect on life prolongation. myo-Inositol trispyrophosphate hexasodium (1.5 g/kg weekly; IV; for 8 weeks) remains metastasis-free on pancreatic carcinomas in immunocompetent male Lewis rats weighing 120-150 g with DSL-6A/C1 cells. myo-Inositol trispyrophosphate hexasodium restores the pO2 pressure in tumors reducing hypoxia-inducible and proangiogenic factors. myo-Inositol trispyrophosphate hexasodium (2 g/kg; once daily for 2 days) shows the most elevated tumour oxygenation at 2 hours in four mouse tumour models (mouse fibrosarcoma FSaII implanted in C3H mice, mouse mammary tumour NT2 in FVb/Nrj mice, human breast cancer MDA‐MB‐231 in NMRI nude mice and human cervix squamous cell carcinoma SiHa in NMRI nude mice) and two rat tumour models (rat 9L‐glioma in Fischer F344 rat
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
参考文献	[1]. Zahary Raykov, et al. Myo-inositol trispyrophosphate-mediated hypoxia reversion controls pancreatic cancer in rodents and enhances gemcitabine efficacy. Int J Cancer. 2014 Jun 1;134(11):2572-82. [2]. Ly-Binh-An Tran, et al. Impact of myo-inositol trispyrophosphate (ITPP) on tumour oxygenation and response to irradiation in rodent tumour models. J Cell Mol Med. 2019 Mar;23(3):1908-1916.

溶解度数据	In Vitro: H₂O : 25 mg/mL (33.88 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

myo-Inositol trispyrophosphate hexasodium

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