Dixyrazine 是 Phenothiazine 衍生物，可预防注射硫酸鱼精蛋白引起的脑水肿。

Dixyrazine, a phenothiazine derivative, can prevent brain oedema induced by intracarotid injection of protamine sulphate.

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Pretreatment with Dixyrazine 10 mg/kg completely prevents the brain oedema and significantly reduces the albumin increase in cerebrospinal fluid (CSF). The phenothiazine Dixyrazine (5 mg/kg i.v.) has minimal, transient hypotensive effects but significantly reduces the leakage of I labelled serum albumin in conscious rats subjected to acute hypertension provoked by i.v. Adrenaline or Bicuculline. The diameters of pial arteries and veins are continuously measured with a multichannel videoangiometer through a closed cranial window in anesthetized rats before and after i.v. injection of Dixyrazine (5 mg/kg). Dixyrazine, 5 mg /kg, induces a slight transitory decrease in blood pressure (10-20 mm Hg). Maximum MAP is slightly but not significantly lower in Dixyrazine-treated rats. has not independently confirmed the accuracy of

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[1]. Westergren I, et al. Dixyrazine, a phenothiazine derivative, can prevent brain oedema induced by intracarotid injection of protamine sulphate. Acta Neurochir (Wien). 1991;113(3-4):171-5.
[2]. Johansson BB, et al. Phenothiazine-mediated protection of the blood-brain barrier during acute hypertension. Stroke. 1982 Mar-Apr;13(2):220-5.

In Vitro: DMSO : 100 mg/mL (233.86 mM; Need ultrasonic)配制储备液