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Neuropeptide S (human)

目录号: PL08215 纯度: ≥98%

Neuropeptide S human，一种神经肽，是一种有效的同源神经肽 S 受体 (NPSR) 激动剂。Neuropeptide S human 可用于阿尔茨海默病 (AD) 的研究。

CAS No. :412938-67-1

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中文名称	Neuropeptide S (human)
英文名称	Neuropeptide S (human)
英文别名	L-Serine,L-seryl-L-phenylalanyl-L-arginyl-L-asparaginylglycyl-L-valylglycyl-L-threonylglycyl-L-methionyl-L-lysyl-L-lysyl-L-threonyl-L-seryl-L-phenylalanyl-L-glutaminyl-L-arginyl-L-alanyl-L-lysyl-;L-Serine,L-seryl-L-phenylalanyl-L-arginyl-L-asparaginylglycyl-L-valylglycyl-L-threonylglycyl-L...;L-Serine,L-seryl-L-phenylalanyl-L-arginyl-L-asparaginylglycyl-L-valylglycyl-L-threonylglycyl-L-methionyl-L-lysyl-L-lysyl-L-th;NEUROPEPTIDE S (HUMAN);Neuropeptide S (human), NPS (human);NEUROPEPTIDE S, HNPS (1-12), HUMAN;H-SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER-OH;Neuropeptide S,NPS,human;REF DUPL: H-Ser-Phe-Arg-Asn-Gly-Val-Gly-Ser-Gly-Ala-Lys-Lys-Thr-Ser-Phe-Arg-Arg-Ala-Lys-Gln-OH;SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER;SFRNGVGTGMKKTSFQRAKS;neuropepetide S;BDBM50412707;Neuropeptide S human trifluoroacetate;Neuropeptide S (human)
Cas No.	412938-67-1
分子式	C₉₃H₁₅₅N₃₁O₂₈S
分子量	2187.48
包装储存	Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years；-20°C 1 ye
详情描述	Neuropeptide S human，一种神经肽，是一种有效的同源神经肽 S 受体 (NPSR) 激动剂。Neuropeptide S human 可用于阿尔茨海默病 (AD) 的研究。

产品详情	Neuropeptide S human，一种神经肽，是一种有效的同源神经肽 S 受体 (NPSR) 激动剂。Neuropeptide S human 可用于阿尔茨海默病 (AD) 的研究。
生物活性	Neuropeptide S human, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human can be used for Alzheimers disease (AD) research.
性状	Solid
IC50 & Target[1][2]	EC50: 9.4 nM (neuropeptide S receptor)
体外研究(In Vitro)	Half-maximal effective concentrations (EC50) for mobilization of [Ca]i are 9.4 nM, 3.2 nM, and 3.0 nM for human, rat, and mouse Neuropeptide S (NPS), respectively. Neuropeptide S human (4 pM to 1.7 nM; 48 hours) retains full agonist activity with an EC50 of 6.7 nM, the binding of [] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (Kd = 0.33 nM). Neuropeptide S human (1 pM-3 μM; 48 hours) are used to compete with 0.15 nM [I] Y10-NPS, [I] Y10-NPS is displaceable by increasing concentrations of human NPS (IC50 = 0.42 nM). has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Neuropeptide S human (0.1 nM-1 nM; i.c.v.) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years；-20°C 1 ye
SequenceShortening	SFRNGVGTGMKKTSFQRAKS
Sequence	Ser-Phe-Arg-Asn-Gly-Val-Gly-Thr-Gly-Met-Lys-Lys-Thr-Ser-Phe-Gln-Arg-Ala-Lys-Ser
参考文献	[1]. Xu YL, et al. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects.Neuron. 2004 Aug 19;43(4):487-97.

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[1]. Xu YL, et al. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects.Neuron. 2004 Aug 19;43(4):487-97.

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Neuropeptide S (human)

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