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Chelidamic acid

目录号: PL08241 纯度: ≥98.0%

Chelidamic acid 是一种含有吡喃骨架的杂环有机酸，与金属离子有良好的配位能力。Chelidamic acid 也是最有效的谷氨酸脱羧酶 (glutamate decarboxylase) 抑制剂之一，其 Ki 值为 33 μM。

CAS No. :138-60-3

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中文名称	Chelidamic acid
中文别名	单水白屈氨酸;白屈氨酸水合物;4-氧代-1,4-二氢-2,6-吡啶二甲酸;4-羟基-2,6-二吡啶甲酸;4-羟基吡啶-2,6-二甲酸;4-羟基吡啶-2,6-二甲酸水合物;Chelidamic Acid Monohydrate 白屈氨酸一水合物;白屈氨酸;白屈氨酸一水合物;4-羟;4-羟基吡啶-2,6-二羧酸;4-氧代-1,4-二氢吡啶-2,6-二羧酸;4-氧代-1,4-二氢-2,6-吡啶二甲酸水合物;白居氨酸;白屈原酸;白屈菜胺酸;白屈氨酸一水物;4-羟基-2,6-二羧酸;白屈氨酸水合物,97%
英文名称	Chelidamic acid
英文别名	4-Oxo-1,4-dihydropyridine-2,6-dicarboxylic acid;1,4-Dihydro-4-oxo-2,6-pyridinedicarboxylic acid hydrate;4-Hydroxypyridine-2,6-dicarboxylic acid hydrate;Chelidamic aicd;Chelidamic acid hydrate;Chelidamic Acid;4-Hydroxypyridine-2,6-dicarboxylic acid;4-Oxo-1,4-dihydro-pyridine-2,6-dicarboxylic acid;.HELIDAMIC AICD;1,4-dihydro-4-oxo-2,6-pyridinedicarboxylic acid;4-Hydroxypyridine-2,6-dicarboxylic Acid Monohydrate;4-oxo-1,4-dihydro-2,6-pyridinedicarboxylic acid;4-PYRIDONE-2,6-DICARBOXYLIC ACID;Ammox-chelidonic acid;Chelid;Chelidamaic acid;Chelidamic Acid Monohydrate;Pd(OH)2;4-Hydroxy-pyridine-2,6-dicarboxylic acid;Nsc3983;AKOS 90653;Chelidamic acid AldrichCPR;Pd(OH)2/C20%;chelidamic acid approx. 95%;2,6-Pyridinedicarboxylic acid, 1,4-dihydro-4-oxo-;4-HYDROXY-2,6-PYRIDINEDICARBOXYLIC ACID;1A59BH8SXE;4-oxo-1H-pyridine-2,6-dicarboxylic acid;1,4-Dihydro-4-oxopyridine-2,6-dicarboxylic acid;2,6-Pyridinedicarboxylic acid, 4-hydroxy-;Chelidamic acid hydrate, 97%;4-oxohydropyridine-2,6-dicar;4-Oxo-1,4-dihydro-2,6-pyridinedicarboxylic acid;CHELIDAMIC ACID;CHELIDAMIC ACID;CHELIDAMIC ACID HYDRATE;CHELIDAMIC ACID HYDRATE;Chelidamic acid
Cas No.	138-60-3
分子式	C₇H₅NO₅
分子量	183.12
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	Chelidamic acid 是一种含有吡喃骨架的杂环有机酸，与金属离子有良好的配位能力。Chelidamic acid 也是最有效的谷氨酸脱羧酶 (glutamate decarboxylase) 抑制剂之一，其 Ki 值为 33 μM。

产品详情	Chelidamic acid 是一种含有吡喃骨架的杂环有机酸，与金属离子有良好的配位能力。Chelidamic acid 也是最有效的谷氨酸脱羧酶 (glutamate decarboxylase) 抑制剂之一，其 K_i 值为 33 μM。
生物活性	Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid has good coordination ability with noble metal ions. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a K i of 33 μM.
性状	Solid
IC50 & Target[1][2]	Ki: 33 μM (Glutamate decarboxylase).
体外研究(In Vitro)	Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid has good coordination ability with noble metal ions. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Searcey M, et al. Synthesis, DNA-cleaving properties and cytotoxicity of intercalating chelidamic acid derivatives. Anticancer Drug Des. 13(8):837-55. [2]. Espinet P, et al. Mesogenic palladium complexes with pincer ligands derived from dipicolinic acid. Inorg Chem. 2000 Aug, 7;39(16):3645-51.

溶解度数据	In Vitro: DMSO : 10 mg/mL (54.61 mM; Need ultrasonic)H₂O : 1 mg/mL (5.46 mM; Need ultrasonic)配制储备液

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[1]. Searcey M, et al. Synthesis, DNA-cleaving properties and cytotoxicity of intercalating chelidamic acid derivatives. Anticancer Drug Des. 13(8):837-55.
[2]. Espinet P, et al. Mesogenic palladium complexes with pincer ligands derived from dipicolinic acid. Inorg Chem. 2000 Aug, 7;39(16):3645-51.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Chelidamic acid

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