FR183998 free base 是一种有效的 Na⁺/H⁺-exchange 抑制剂，通过测量在大鼠淋巴细胞、血小板及人血小板 pH_i 值的变化中，得到 IC₅₀ 值分别为 0.3 nM，6.5 nM 和 3.1 nM。

FR183998 free base is a potent Na/H-exchange inhibitor, with IC 50 s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pH i change in rat lymphocytes, rat and human platelets, respectively.

Solid

IC50: 0.3 nM (Na/H-exchange, Rat lymphocytes), 3.1 nM (Na/H-exchange, Human platelet), 6.5 nM (Na/H-exchange, Rat platelet)

FR183998 free base is a Na/H-exchange inhibitor, with IC50s of 0.3 nM, 6.5 nM and 3.1 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.

FR183998 (0.1 and 1.0 mg/kg, i.v.) shows no effect hemodynamic parameters, and does not affect mean blood pressure and heart rate in conscious rats. Pretreatment of 0.01, 0.032, 0.10 mg/kg FR183998 or posttreament of 0.032 and 0.10 mg/kg FR183998 via intravenous administration, dose-dependently reuces reperfusion-induced ventricular fibrillation (VF) and mortality in reperfusion-induced arrhythmias in anesthetized rats, with ED 50 s against VF of 0.015 mg/kg and 0.070 mg/kg, respectively. FR183998 also reduces myocardial infarct sizes, and suppresses the arrhythmias in anesthetized rats. FR183998 (1 mg/kg, i.v.) reduces the increase in serum levels of alanine transaminase, aspartate transaminase, and lactate dehydrogenase induced by hepatic I/R, and prevents the incidences of hepatic necrosis, apoptosis, and neutrophil infiltration. FR183998 blocks the I/R-induced act

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；In solvent -80°C 6 months

[1]. Ohara F, et al. Preischemic and postischemic treatment with a new Na+/H+-exchange inhibitor, FR183998, shows cardioprotective effects in rats with cardiac ischemia and reperfusion. J Cardiovasc Pharmacol. 1999 Dec;34(6):848-56.
[2]. Ishizaki M, et al. Protective effect of FR183998, a Na+/H+ exchanger inhibitor, and its inhibition of iNOS induction in hepatic ischemia-reperfusion injury in rats. Shock. 2008 Sep;30(3):311-7.

In Vitro: DMSO : 250 mg/mL (583.65 mM; Need ultrasonic)配制储备液