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Fenamic acid

目录号: PL06475 纯度: ≥98%

Fenamic acid (N-Phenylanthranilic acid, NPAA) 是一种具有口服活性的氯通道阻滞剂。Fenamic acid 是非甾体抗炎剂 (NSAIA) 的基本成分，可衍生甲芬那酸 (mefenamic)，托芬那酸 (tofenacin)，氟芬那酸 (flufenamic acid) 和美洛芬酸 (melofenac acid)。Fenamic acid 也可作为抗菌和镇痛剂。

CAS No. :91-40-7

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PL06475-50mg	50mg	¥243.00	请登录
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PL06475-200mg	200mg	¥524.00	请登录
PL06475-10mM*1mLinDMSO	10mM*1mLinDMSO	¥884.00	请登录
PL06475-1 mL x 10 mM (in DMSO)		¥268.00	请登录

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中文名称	Fenamic acid
中文别名	芬那酸;钒试剂;N-苯基氨茴酸;N-苯基邻氨基苯甲酸;N-苯基邻氨基苯甲酸(钒试剂);(钒试剂)苯基邻-氨基苯甲酸;(钒试剂)苯基邻-氨基苯甲酸,AR;N-Phenylanthranilic Acid N-苯基邻氨基苯甲酸;Nα-苄氧羰基-L-组氨酸;N-苯基代邻氨基苯甲酸;N-苯基蒽酸;苯基邻-氨基苯甲酸（钒试剂）,AR;芬那酸钒试剂;2-(苯基氨基)苯甲酸;2-苯氨基苯甲酸;N-苯基代邻位氨基苯酸;苯代邻氨基苯甲酸;苯基代邻氨基苯甲酸;二苯胺-2-羧酸;芬那酸,N-苯基氨茴酸,苯基邻-氨基苯甲酸;邻苯胺苯甲酸;2-(苯氨基)苯甲酸;甲芬那酸
英文名称	Fenamic acid
英文别名	N-Phenylanthranilic acid;Diphenylamine-2-carboxylic acid;N-Phenyl 2-Aminobenzoic Acid;Benzoic acid, 2-(phenylamino)-;N-Phenyl o-aminobenzoic acid;2-anilinobenzoic acid;DPC;2-(Phenylamino)benzoic acid;Fenamic acid;Phenylanthranilic acid;2-Carboxydiphenylamine;o-Anilinobenzoic acid;N-Phenyl-o-aminobenzoic acid;N-Phenyl-2-aminobenzoic acid;Anthranilic acid, N-phenyl-;2-Phenylamino-benzoic acid;N-Phenylanthranilic;952VN06WBB;ZWJINEZUA;NCGC00093536-04;CHEMBL23832;AKOS000118791;2-phenylazanylbenzoic acid;KBio2_002302;FT-0631438;HMS3402H03;CBDivE_001949;HMS3373F04;MLS-0412242.P016;NCGC00014989-06;EINECS 202-066-8;diphenylamine carboxylate;NCGC00014989-02;NCGC00093536-02;PhenylanthranilsA currencyure;BCBcMAP01_000076;SY048561;NCGC00014989-07;ZWJINEZUASEZBH-UHFFFAOYSA-;HMS2232G15;SB78726;W-100309;F3145-3322;Z57127451;KBioSS_002304;AMY40863;BRN 1456607;N-PHENYLANTHRANILIC ACID [MI];KBio3_000282;BIDD:GT0820;DPC cpd;Bio1_000122;DTXSID6059025;KBio2_004870;DS-14719;D03APP;SPECTRUM1505156;STK089446;Bio1_001100;NCGC00093536-06;LP00011;BB 0255314;ortho-anilinobenzoic acid;KBio2_007438;NCGC00093536-03;NSC-4273;KBio3_000281;N-phenylanthranilsyre;HMS1361H03;BRD-K80863915-001-02-9;EN300-18386;N-phenyl-ortho-aminobenzoic acid;phenyl anthranilic acid;NSC 215211;HY-W040265;2-anilino-benzoic acid;SR-01000075342;KBioGR_002302;Bio1_000611;KBio2_000141;HMS1791H03;KBioGR_000141;o-(Phenylamino)benzoic acid;KBio2_002709;KBio3_002782;NSC-215211;SCHEMBL25828;A843855;D0873;CBiol_001836;N-phenylanthranilic acid;Tox21_500011;N-Phenylanthranilic acid, 98%;N-Phenylanthranilic acid, technical, >=95% (T);NCGC00014989-05;GTPL4182;EU-0100011;BBL008122;Phenyl anthranilic acid (all isomers);NCGC00093536-01;Lopac0_000011;D70372;NCGC00014989-03;CHEBI:34756;s5517;AE-641/02494034;Oprea1_622264;IDI1_033891;MLS-0412242;Bio2_000621;NCGC00014989-01;InChI=1/C13H11NO2/c15-13(16)11-8-4-5-9-12(11)14-10-6-2-1-3-7-10/h1-9,14H,(H,15,16);SR-01000075342-1;SDCCGMLS-0412242.P028;AI3-08880;NSC215211;BSPBio_001421;Diphenylamine-2-carboxylic acid; DPC;KBioSS_000141;SMR001230825;SR-01000075342-2;n-phenyl anthranilic acid;NCGC00014989-04;NSC4273;CS-W021005;NCGC00093536-05;91-40-7;BRD-K80863915-001-05-2;HMS3260C03;HMS1989H03;LS-20563;Lopac-144509;MFCD00002421;cMAP_000012;KBio2_005277;SDCCGSBI-0050000.P002;Diphenylaminecarboxylic acid-(2);Oprea1_414882;NCGC00014989-12;NCGC00260696-01;N-phenyl-anthranilic acid;BDBM50337278;NCGC00014989-08;UNII-952VN06WBB;diphenylamine-2-carboxylate;Bio2_000141;Q498436;MLS002153472;CCG-204107;2-Anilinobenzoic acid;2-Anilinobenzoic Acid;Diphenylamine-2-carboxylic Acid;2-(Phenylamino)benzoic acid (ACI);Anthranilic acid, N-phenyl- (6CI, 7CI, 8CI);Diphenylamine-2-carboxylate;DPC (chloride channel inhibitor);NSC 4273;o-Carboxydiphenylamine
Cas No.	91-40-7
分子式	C₁₃H₁₁NO₂
分子量	213.23
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
详情描述	Fenamic acid (N-Phenylanthranilic acid, NPAA) 是一种具有口服活性的氯通道阻滞剂。Fenamic acid 是非甾体抗炎剂 (NSAIA) 的基本成分，可衍生甲芬那酸 (mefenamic)，托芬那酸 (tofenacin)，氟芬那酸 (flufenamic acid) 和美洛芬酸 (melofenac acid)。Fenamic acid 也可作为抗菌和镇痛剂。

产品详情	Fenamic acid (N-Phenylanthranilic acid, NPAA) 是一种具有口服活性的氯通道阻滞剂。Fenamic acid 是非甾体抗炎剂 (NSAIA) 的基本成分，可衍生甲芬那酸 (mefenamic)，托芬那酸 (tofenacin)，氟芬那酸 (flufenamic acid) 和美洛芬酸 (melofenac acid)。Fenamic acid 也可作为抗菌和镇痛剂。
生物活性	Fenamic acid (N-Phenylanthranilic acid, NPAA) is an orally active chloride channel blocker. Fenamic acid is the basic constituent of non-steroidal anti-inflammatory agents (NSAIA), and derives into mefenamic, tofenacin, flufenac acid and melofenac acid. Fenamic acid also acts as antibacterial and analgesic agent.
性状	Solid
IC50 & Target[1][2]	Chloride Channel
体外研究(In Vitro)	Fenamic acid (N-Phenylanthranilic acid, NPAA) (2.5 mM; 3 h) inhibits Cl transportation and blocks C1 uptake and efflux in endothelial cells. Fenamic acid exhibits selectivity to AKR1B10 (the tumor-marker) over human AR, and inhibits AKR1B10 with IC50s of 0.76 μM (Flufenamic acid), 1.6 μM (Mefenamic acid), 9.89 μM (Meclofenamic acid), respectively. Fenamic acid (4-16 μg/mL; 72 h) inhibits 50% of Neisseria gonorrhoeae with an MIC50 value from 4 to 16 μg/mL (tolfenamic acid, flufenamic acid, and meclofenamic acid) in a low frequency of resistance. Fenamic acid (2-8 μg/mL; 8 h) reduces the expression of the porinflammatory cytokines (IL-8, IL-6 and IL-?) by infected endocervical cells without (>128 μg/mL; 24 h) inhibition towards commensal Lactobacillus spp. belonging healthy female genital microbiota.
体内研究(In Vivo)	RPA-1 is a biomarker in the detection of collecting duct injury in papillary necrosis in male rats. Fenamic acid (N-Phenylanthranilic acid, NPAA) (350-700 mg/kg/day; o.p.; 4 d, 8 d, and 15 d) causes renal papillary necrosis and increases urinary renal papillary antigen-1 (RPA-1) in rats. Fenamic acid (20 g/0.2 mL; i.p.) shows inhibitory effect against the abdominal constriction induced by acetic acid in mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Mandel KG, et al. Characterization of a cyclic AMP-activated Cl-transport pathway in the apical membrane of a human colonic epithelial cell line. J Biol Chem. 1986 Jan 15. 261(2):704-12. [2]. Ueda S, et al. Chloride efflux in cyclic AMP-induced configurational change of bovine pulmonary artery endothelial cells. Circ Res. 1990 Apr. 66(4):957-67.

溶解度数据	In Vitro: DMSO : 125 mg/mL (586.22 mM; Need ultrasonic)H₂O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)配制储备液

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[1]. Mandel KG, et al. Characterization of a cyclic AMP-activated Cl-transport pathway in the apical membrane of a human colonic epithelial cell line. J Biol Chem. 1986 Jan 15. 261(2):704-12.
[2]. Ueda S, et al. Chloride efflux in cyclic AMP-induced configurational change of bovine pulmonary artery endothelial cells. Circ Res. 1990 Apr. 66(4):957-67.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Fenamic acid

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