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4-Diethylaminobenzaldehyde

目录号: PL06408 纯度: ≥98%

4-Diethylaminobenzaldehyde 是一种可逆的醛脱氢酶 (ALDHs) 抑制剂，对 ALDH1 的 Ki 为 4 nM。4-Diethylaminobenzaldehyde 具有较强的抗雄激素作用 (IC50= 1.71 μM)。

CAS No. :120-21-8

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中文名称	4-Diethylaminobenzaldehyde
中文别名	4-(N,N-二乙基)氨基苯甲醛;N,N-二乙基-4-氨基苯甲醛;4-二乙基氨基苯甲醛;4-二乙氨基苯甲醛;4-Diethylaminobenzaldehyde 4-二乙氨基苯甲醛;4-二乙氨基苯甲醛(DEAM);4-二乙胺基苯甲醛;BETA-律草烯;对二乙氨基苯甲醛;N,N-二乙氨基苯甲醛;对二乙胺基苯甲醛;二乙基氨苯甲醯;对二乙氯基苯甲醚;对-二乙氨基苯甲醛;P-二乙胺基苯甲醛
英文名称	4-Diethylaminobenzaldehyde
英文别名	4-(Diethylamino)benzaldehyde;4-(Diethylamino)-Benzaldehyde;p-N,N-Diethylaminobenzaldehyde;4-Diethylaminobenzoaldehyde;4-N,N-diethylaminobenzaldehyde;N,N-Diethyl-4-amino benzaldehyde;DEAB;4-Diethylaminobenzal;p-Diethylaminobenzaldehyd;(diethylamino)benzaldehyde;4-DIETHYLAMINOBENZALDEHYDE;P-DIETHYLAMINOBENZALDEHYDE;P-FORMYL-N,N-DIETHYLANILINE;AKOS BBS-00003202;LABOTEST-BB LT00924385;Benzaldehyde, 4-(diethylamino)-;p-(Diethylamino)benzaldehyde;Benzaldehyde, p-(diethylamino)-;4-(N,N-Diethylamino)benzaldehyde;S640XWL10H;MNFZZNNFORDXSV-UHFFFAOYSA-N;4-(N,N-diethylamino)-benzaldehyde;4-(Diethylamino)benzaldehyde,
Cas No.	120-21-8
分子式	C₁₁H₁₅NO
分子量	177.24
包装储存	4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
详情描述	4-Diethylaminobenzaldehyde 是一种可逆的醛脱氢酶 (ALDHs) 抑制剂，对 ALDH1 的 Ki 为 4 nM。4-Diethylaminobenzaldehyde 具有较强的抗雄激素作用 (IC50= 1.71 μM)。

产品详情	4-Diethylaminobenzaldehyde 是一种可逆的醛脱氢酶 (ALDHs) 抑制剂，对 ALDH1 的 K_i 为 4 nM。4-Diethylaminobenzaldehyde 具有较强的抗雄激素作用 (IC₅₀= 1.71 μM)。
生物活性	4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenases (ALDHs) inhibitor, with a K i of 4 nM for ALDH1. 4-Diethylaminobenzaldehyde displays potent anti-androgenic effect (IC 50 = 1.71μM).
性状	Solid
体外研究(In Vitro)	4-Diethylaminobenzaldehyde (DEAB) is reversible competitive inhibitor of ALDH1 (competitive with the aldehyde substrate) with a Ki value of 4 nM, and irreversibly inactivates ALDH7A1 via formation of a stable, covalent acyl-enzyme species. The Temozolomide (TMZ)-resistant cell line LN18 is treated with a combination of TMZ and 4-Diethylaminobenzaldehyde for 10 days. As indicated by colony formation assay, the clonogenic capacity of LN18 cells exposed to TMZ in combination with 4-Diethylaminobenzaldehyde (DEAB) is significantly attenuated. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献	[1]. Luo M, et al. Diethylaminobenzaldehyde is a covalent, irreversible inactivator of ALDH7A1. ACS Chem Biol. 2015 Mar 20;10(3):693-7. [2]. Araki N, et al. Screening for androgen receptor activities in 253 industrial chemicals by in vitro reporter gene assays using AR-EcoScreen cells. Toxicol In Vitro. 2005 Sep;19(6):831-42.

溶解度数据	In Vitro: DMSO : 100 mg/mL (564.21 mM; ultrasonic and warming and heat to 60°C)配制储备液

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[1]. Luo M, et al. Diethylaminobenzaldehyde is a covalent, irreversible inactivator of ALDH7A1. ACS Chem Biol. 2015 Mar 20;10(3):693-7.
[2]. Araki N, et al. Screening for androgen receptor activities in 253 industrial chemicals by in vitro reporter gene assays using AR-EcoScreen cells. Toxicol In Vitro. 2005 Sep;19(6):831-42.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

4-Diethylaminobenzaldehyde

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