Aranidipine|86780-90-7|(阿雷地平; MPC1304)-陌孚医药/Medlife

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Aranidipine (Synonyms: 阿雷地平; MPC1304)

目录号: PL06127 纯度: ≥98%

CAS No. :86780-90-7

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中文名称	Aranidipine
中文别名	阿雷地平;2,6-二甲基-4-(2-硝基苯基)-1,4-二氢-3,5-吡啶二羧酸甲基2-氧丙基酯
英文名称	Aranidipine
英文别名	3-Methyl 5-(2-oxopropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;MPC-1304;Sapresta;1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(2-oxopropyl) ester;Asanidipine;3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, 3-methyl 5-(2-oxopropyl)ester;3-O-methyl 5-O-(2-oxopropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;Aranidipine;2,6-Dimethyl-4-(2-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid methyl 2-oxopropyl ester
Cas No.	86780-90-7
分子式	C₁₉H₂₀N₂O₇
分子量	388.37
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Aranidipine (MPC1304) 是一种钙离子 (Ca²⁺) 通道拮抗剂，具有强大而持久的抗高血压作用。
生物活性	Aranidipine (MPC1304) is a Ca channel antagonist with potent and long-lasting antihypertensive effects.
性状	Solid
IC50 & Target[1][2]	Ca Channel
体内研究(In Vivo)	Aranidipine (MPC-1304) is a new Ca channel antagonist in spontaneously hypertensive rats. Following oral administration of Aranidipine at doses of 3 and 10 mg/kg to spontaneously hypertensive rats (SHR), there are significant decreases in B max values for specific [H](+)-PN 200-110 binding to myocardial membranes compared to the control values. The B max values at 1 h (3 mg/kg), 1 and 6 h (10 mg/kg) are significantly decreased (47.7, 48.9 and 25.8%, respectively) compared to the control values. The effect is greatest at 1 h and decreases with time. The B max values at 6 h (3 mg/kg) and 12 or 24 h (10 mg/kg) after the oral administration of Aranidipine are not significantly different from the control values, suggesting the disappearance of the effect of Aranidipine. The K d values for myocardial [H](+)-PN 200-110 binding are unaltered by
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Nozawa Y, et al. Receptor occupation and pharmacokinetics of MPC-1304, a new Ca channel antagonist, in spontaneously hypertensive rats. Eur J Pharmacol. 1995 Dec 12;287(2):191-6.

溶解度数据	In Vitro: DMSO : 125 mg/mL (321.86 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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