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Sodium gualenate

目录号: PL05582 纯度: ≥98%

Sodium gualenate (Guaiazulenesulfonate sodium) 是桂皮烯的亲水性衍生物，具有优良的抗炎和愈伤作用，主要用于研究十二指肠溃疡，胃溃疡和胃炎。

CAS No. :6223-35-4

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中文名称	Sodium gualenate
中文别名	磺酸钠;薁磺酸钠;愈创木薁磺酸钠;呱仑酸钠;1,4-二甲基-7-异丙基甘菊环-3-磺酸钠;奥磺酸钠;7-异丙基-1,4-二甲基甘菊蓝-3-磺酸钠盐;7-异丙基-1,4-二甲基甘菊环-3-磺酸钠;5-异丙基-3,8-二甲基甘菊环-1-磺酸钠盐;薁磺酸钠;愈创木奥磺酸钠
英文名称	Sodium gualenate
英文别名	Sodium 5-isopropyl-3,8-dimethylazulene-1-sulfonate;Sodium Gualenate [INN];1-Azulenesulfonic acid, 3,8-dimethyl-5-(1-methylethyl)-, sodium salt;3,8-Dimethyl-5-(1-methylethyl)-1-azulenesulfonic acid, sodium salt;Guaiazulene 3-sulfonate sodium salt;Sodium 3,8-dimethyl-5-(1-methylethyl)-1-azulenesulfonate;Sodium guiazulene sulfonate;Azulen SN;Azulon;Azupromin;CCRIS 3781;Guajazulen-3-sulfonsaeure, natriumsalz;Gualenate de sodium;Gualenate de sodium [INN-French];Gualenato sodico;Gualenato sodico [INN-Spanish];Gualenato sodidico;Natrii gualenas;Natrii gualenas [INN-Latin];Natrium 7-isopropyl-1,4-dimethyl-3-azulensulfonat;Sodium 5-isopropyl-3,8-dimethyl-1-azulene sulfonate;Sodium 7-isopropyl-1,4-dimethylazulene-3-sulfonate;Sodium guaiazulene-3-sulfonate;1-Azulenesulfonic acid, 3,8-dimethyl-5-(1-methylethyl)-, sodium salt (9CI);1-Azulenesulfonic acid, 5-isopropyl-3,8-dimethyl-, sodium salt;Azuletil sodium;sodium 3,8-dimethyl-5-(propan-2-yl)azulene-1-sulfonate;1,4-Dimethyl-7-Isopropylazulene-3-Sulfonate Sodium Salt;Guaiazulenesulfonate sodium;sodium,3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate;5-Isopropyl-3,8-dimethyl-azulen-1-sulfonsaeure,Natrium-Salz;5-isopropyl-3,8-dimethyl-azulene-1-sulfonic acid,sodium-salt;Azulene sulfonate sodium;sodium gualenate;Guaiazulenesulfonic Acid Sodium Salt;5-Isopropyl-3,8-dimethylazulene-1-sulfonic Acid Sodium Salt;7-Isopropyl-1,4-dimethyl-azulene-3-sulfonic Acid Sodium Salt;Sodium Guaiazulenesulfonate;Sodium 1,4-dimethyl-7-isopropylazulene-3-sulfonate;Sodium Guaiazulene Sulfonate;Sodium Gualenate;Sodium 5-Isopropyl-3,8-dimethylazulene-1-sulfonate
Cas No.	6223-35-4
分子式	C₁₅H₁₇NaO₃S
分子量	300.35
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	Sodium gualenate (Guaiazulenesulfonate sodium) 是桂皮烯的亲水性衍生物，具有优良的抗炎和愈伤作用，主要用于研究十二指肠溃疡，胃溃疡和胃炎。

产品详情	Sodium gualenate (Guaiazulenesulfonate sodium) 是桂皮烯的亲水性衍生物，具有优良的抗炎和愈伤作用，主要用于研究十二指肠溃疡，胃溃疡和胃炎。
生物活性	Sodium gualenate (Guaiazulenesulfonate sodium) is a hydrophilic derivative of guaiazulene with excellent anti-inflammatory and wound-healing effects mainly used for the treatment of duodenal ulcer, gastric ulcer and gastritis.
性状	Solid
体外研究(In Vitro)	Sodium gualenate is an unstable compound, which is gradually decomposed in the solid state at room temperature. When heated, Sodium gualenate decomposes almost completely within 1 week. It was found that a kneaded mixture of Sodium gualenate and cornstarch (weight ratio; 1:250) for tableting with water is stable. So, during production, Sodium gualenate could be stabilized using water. Sodium gualenate slightly inhibits the histamine release from rat peritoneal mast cells and strongly inhibits the leukocyte emigration induced by fMLP. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Sodium gualenate has been frequently used for the treatment of human gastritis. Cytoprotection is defined as the main mechanism of Sodium gualenate to protect the mucosa of the stomach and the antipeptic actions in vivo have also been shown. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Nakamichi K, et al. Stabilization of sodium guaiazulene sulfonate in granules for tableting prepared using a twin-screw extruder. Eur J Pharm Biopharm. 2003 Nov;56(3):347-54. [2]. Cao T, et al. Synthesis and Biological Evaluation of 3, 8-dimethyl-5-isopropylazulene Derivatives as Anti-gastric Ulcer Agent. Chem Biol Drug Des. 2016 Aug;88(2):264-71.

溶解度数据	In Vitro: DMSO : 25 mg/mL (83.24 mM; Need ultrasonic)H₂O : 6.25 mg/mL (20.81 mM; ultrasonic and warming and heat to 60°C)配制储备液

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[1]. Nakamichi K, et al. Stabilization of sodium guaiazulene sulfonate in granules for tableting prepared using a twin-screw extruder. Eur J Pharm Biopharm. 2003 Nov;56(3):347-54.
[2]. Cao T, et al. Synthesis and Biological Evaluation of 3, 8-dimethyl-5-isopropylazulene Derivatives as Anti-gastric Ulcer Agent. Chem Biol Drug Des. 2016 Aug;88(2):264-71.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Sodium gualenate

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