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Quadrol

目录号: PL05575 纯度: ≥98%

Quadrol 是一种免疫刺激剂，已被认为是加速伤口愈合的潜在有用药物。

CAS No. :102-60-3

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中文名称	Quadrol
中文别名	四羟丙基乙二胺;N,N,N’,N’-四(2-羟基丙基)乙二胺;N,N,N',N'-四-（2羟基丙基）乙二胺;乙二胺-N,N,N',N'-四丙-2-醇;N,N,N',N'-四(2-羟丙基)乙二胺;(乙烯二腈)四-2-丙醇;依的托;依地醇;N,N,N',N'-肆(2-羥丙)乙二醇;四羟丙基乙二胺（Q75）;N,N,N,N-四(2-羟基丙基)乙二胺;N,N,N’,N‘-四(2-羟基丙基)乙二胺;N,N,N',N'-四(2-羟基丙基)乙二胺;(2-硝基苯基)-β-D-葡糖苷酸;EDTP(N,N,N'N'-四(2-羟丙基)乙二胺);EDTP（Q75） N,N,N,1,N1-四（2羟丙基）乙二胺;EDTP(Q75)(N,N,N'N'-四(2-羟丙基)乙二胺);EDTP四羟丙基乙二胺;N,N,N ,N -四(2-羟丙基)乙二胺;N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine N,N,N',N'-四(2-羟丙基)乙二胺;N,N,N,'N'-四(2-羟丙基)乙二胺EDTP四羟丙基乙二胺依地醇;N,N,N',N'-四-(2-羟基丙基)乙二胺;N,N,N,N-四(2-羟基丙基)乙烯二胺;N,N,N\',N\'-四-(2羟基丙基)乙二胺;N,N,N’,N’-四(2-羟基丙基)乙二胺缓冲剂;N,N,N’N’-四(2-羟丙基)乙二胺;N,N,N′,N′-四(2-羟丙基)乙二胺;化学沉铜络合剂助焊剂 EDTP（BASF Q75）;四羟丙基乙二胺 EDTP,Q75;四羟丙基乙二胺EDTP（Q75）;2,5-双甲基苯胺;N,N,N'',N''-四(2-羟基丙基)乙二胺;N,N,N’N’-四(2-羟丙基)乙二胺);乙二胺-N,N,N`,N`-四丙-2-醇;乙二胺-N,N,N',N'-四-2-丙醇;1,1',1'',1'''-(亚乙基次氮基)四-2-丙醇;依地醇依的托;乙二胺-N,N,N',N'-四-2-醇;N,N,N,1,N1-四(2羟丙基)乙二胺
英文名称	Quadrol
英文别名	1,1',1'',1'''-(Ethane-1,2-diylbis(azanetriyl))tetrakis(propan-2-ol);(ethylenedinitrilo)tetra-2-propanol;edtp;edetol;quadrol buffer;ethylenediamine-n,n,n,n-tetra-2-propanol;n,n,nn-tetrakis(2-hydroxypropyl)ethylenediamine;quadrol;n,n,n,'n'-tetra(2-hydropropayl) ethylene diamine;1,1',1'',1'''-(1,2-ethanediyldinitrilo)tetrakis-2-propano;1,1',1'',1'''-(1,2-ethanediyldinitrilo)tetrakis-2-propanol;1,1',1'',1'''-(ethylenedinitrilo)tetra-2-propano;1,1',1'',1'''-ethane-1,2-diylbisazanediyl-tetrakis-propan-2-ol;1,1',1'',1'''-ethylenedinitrilotetrapropan-2-ol;adekaquadrol;entprol;n,n,n1,n1-tetrakis;n,n,n1,n1-tetrakis(2-hydroxypropyl)ethylenediamine quadroll;tetrakis(2-hydroxypropyl)ethylenediamine;tetrakis-[n-(2-hydroxy-propyl)]-ethylenediamine;tetrakis-n-(2-hydroxy-propyl)-ethane-1,2-diamine;tetrakis-n-(2-hydroxy-propyl)-ethylenediamine;n,n,n',n'-tetra(2-hydroxy-propyl)ethylenediamine;ethylenediamine-n,n,n',n'-tetra-2-propanol;1,1',1'',1'''-(ethylenedinitrilo)tetra-2-propanol;1,1',1'',1'''-(ethylenedinitrilo)tetrakis(2-propanol) tetrahydroxypropyl ethylenediamine;Q75;N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine;1,1',1'',1'''-(Ethane-1,2-diylbis(azanetriyl))-tetrakis(propan-2-ol);N,N,N,N-Tetrakis(2-Hydroxypropyl)- Ethylenediamine;N.N.N'.N'-Tetrakis(2-hydroxypropyl)ethylenediamine;N,N,N′,N′-Tetrakis(2-hydroxypropyl)ethylenediamine;N,N,N’N’-tetra(2-hydropropyl)ethylene diamine;Quadrol®;quadroll;Quadrol(R);EDTP ( Q75);Adeka Quadrol;Quadrol L;Neutrol TE;THPE;Edetolum [Latin];2-Propanol, 1,1',1'',1'''-(1,2-ethanediyldinitrilo)tetrakis-;Edetol [USAN:INN];N,N,N',N'-Tetra(2-hydroxypropyl)ethylenediamine;Tetrahydroxypropyl ethylenediamine;Ethylenediamine-N,N,N',N'-tetra-2-prop;EDTP;Ethylenediamine-N,N,N',N'-tetra-2-propanol;1,1',1'',1'''-(Ethylenedinitrilo)tetra-2-propanol;(Ethylenedinitrilo)tetra-2-propanol;Quadrol;EDETOL;QUADROL;QUADROL BUFFER
Cas No.	102-60-3
分子式	C₁₄H₃₂N₂O₄
分子量	292.41
包装储存	Pure form -20°C 3 years；4°C 2 years
详情描述	Quadrol 是一种免疫刺激剂，已被认为是加速伤口愈合的潜在有用药物。

产品详情	Quadrol 是一种免疫刺激剂，已被认为是加速伤口愈合的潜在有用药物。
生物活性	Quadrol is an immunostimulant and has been implicated as a potentially useful agent in accelerated wound healing.
性状	Oil
体外研究(In Vitro)	Results show that viability of macrophages incubated with Quadrol at concentrations of 0.5 mM, 1 mM and 4mM are identical to that for controls. Viability, however, is reduced to 50% of control at concentrations of 16 mM to 32 mM. After four hours, at concentrations of 1 mM and 4 mM, Quadrol produces enhanced spreading of 88% and 80%, respectively, as compared to the control of 28%. Quadrol, at a concentration of 16 mM, shows reduced percentage of spreading of macrophages after four hours. Exposure of macrophages to 1.0 mM or 4.0 mM Quadrol concentrations enhances phagocytic activity, 41% and 57%, respectively, over that of the cells exposed to media alone (34%). has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	On day eight after the implantation, the amount of collagen in the implants of normal mice injected with Quadrol exceeds controls by more than 200% (p<0.025). By day 11, the collagen content increases to over 300% higher than controls (p<0.01) and by the end of two weeks after wounding, the time interval typically required for normal and complete wound healing, the collagen accumulated in the implants of the Quadrol-treated mice is about 50% above control (p<0.1). The accumulation of collagen in the implants of Quadrol treated STZ-diabetic mice about 100% above the untreated diabetic control on days 8 to 11. By day 14, the collagen deposition has increased to 200% above the controls (p<0.0 5). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Pure form -20°C 3 years；4°C 2 years
参考文献	[1]. Bhide MV, et al. In vitro stimulation of macrophages by quadrol [N,N,N,N-tetrakis(2-hydroxypropyl)ethylenediamine]. J Immunopharmacol. 1985;7(3):303-12. [2]. Bhide MV, et al. Promotion of wound collagen formation in normal and diabetic mice by quadrol. Immunopharmacol Immunotoxicol. 1988;10(4):513-22.

溶解度数据	In Vitro: Ethanol : 100 mg/mL (341.99 mM; Need ultrasonic)DMSO : 100 mg/mL (341.99 mM; Need ultrasonic)配制储备液

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[1]. Bhide MV, et al. In vitro stimulation of macrophages by quadrol [N,N,N,N-tetrakis(2-hydroxypropyl)ethylenediamine]. J Immunopharmacol. 1985;7(3):303-12.
[2]. Bhide MV, et al. Promotion of wound collagen formation in normal and diabetic mice by quadrol. Immunopharmacol Immunotoxicol. 1988;10(4):513-22.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Quadrol

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