Lemildipine|94739-29-4|(NB-818; NPK-1886)-陌孚医药/Medlife

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Lemildipine (Synonyms: NB-818; NPK-1886)

目录号: PL04917 纯度: ≥98%

CAS No. :94739-29-4

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中文名称	Lemildipine
中文别名	来米地平
英文名称	Lemildipine
英文别名	NB818;NB-818;NPK1886;NPK-1886;Lemildipine;NPK 1886;NB 818;3-Isopropyl 5-methyl (+-)-4-(2,3-dichlorophenyl)-1,4-dihydro-2-(hydroxymethyl)-6-methyl-3,5-pyridinedicarboxylate, carbamate (ester);3,5-Pyridinedicarboxylic acid, 2-(((aminocarbonyl)oxy)methyl)-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-, 5-methyl 3-(1-methylethyl) ester;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(2,3-dichlorophenyl)-2-(hydroxymethyl)-6-methyl-,3-isopropyl 5-methyl ester, carbamate ;3-Isopropyl 5-methyl (±)-4-(2,3-dichlorophenyl)-1,4-dihydro-2-(hydroxymethyl)-6-methyl-3,5-pyridinedicarboxylate, carbamate (ester)
Cas No.	94739-29-4
分子式	C₂₀H₂₂Cl₂N₂O₆
分子量	457.30
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Lemildipine 是一种钙通道阻滞剂。
生物活性	Lemildipine is a new dihydropyridine calcium entry blocker.
性状	Solid
IC50 & Target[1][2]	Calcium entry
体内研究(In Vivo)	Gerbils are treated intraperitoneally with Lemildipine (0.1-3 mg/kg) just after release of the occlusion. Four days after the ischemia, they are fixed by perfusing 10% buffered-formalin, and the neuronal cell density (NCD, cell/mm) in the CA1 subfield is estimated under microscopy. The average NCD in the ischemic control group is 43±10.8 cells/mm, whereas Lemildipine (3 mg/kg) significantly ameliorates DND with an average NCD of 143±24.2 cells/mm (P<0.01). In addition, Lemildipine (3 mg/kg) significantly inhibits delayed neuronal death (DND) at 1, 2 and 4 weeks after transient ischemia: the average NCD of the Lemildipine and ischemic control groups are 80±9.4 (P<0.01) and 43±7.7 cells/mm, 92±13.7 (P<0.05) and 52±9.3 cells/mm, and 57±5.0 (P<0.01) and 43±12.4 cells/mm, respectively. In this experiment, Lemildipine (NB-818) exhibits a protective effect on DND in the h
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Kamei K, et al. Effect of a new calcium entry blocker, NB-818, on delayed neuronal death in the ischemic gerbil hippocampus. Jpn J Pharmacol. 1991 Jul;56(3):279-86. [2]. Nagura J, et al. Cardiovascular effects of NPK-1886, a new dihydropyridine compound with calcium entry blocking activity. Jpn J Pharmacol. 1986 Mar;40(3):399-409.

溶解度数据	In Vitro: DMSO : 100 mg/mL (218.67 mM; Need ultrasonic)配制储备液

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