BEC hydrochloride|222638-67-7|-陌孚医药/Medlife

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BEC hydrochloride

目录号: PL04898 纯度: ≥98%

CAS No. :222638-67-7

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中文名称	BEC hydrochloride
中文别名	S-(2-硼酸基乙基)-L-半胱氨酸盐酸盐;S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE
英文名称	BEC hydrochloride
英文别名	L-Cysteine,S-(2-boronoethyl)-, hydrochloride (1:1);L-Cysteine,S-(2-boronoethyl)-, hydrochloride (9CI);BEC HCl;(R)-2-amino-3-((2-boronoethyl)thio)propanoic acid hydrochloride;BEC (hydrochloride);S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE;BEC hydrochloride;(2R)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid hydrochloride;bec-hydrochloride;BCP25043;S-(2-Boronoethyl)-l-cysteine, HCl;(R)-2-Amino-3-(2-boronoethylthio)propanoic acid hydrochloride;(2R)-2-amino-3-{[2-(dihydroxyboranyl)ethyl]sulfanyl}propanoic acid hydrochloride
Cas No.	222638-67-7
分子式	C₅H₁₃BClNO₄S
分子量	229.49
包装储存	4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

产品详情	BEC hydrochloride 是一种缓慢结合的竞争性精氨酸酶 II ( Arginase II) 抑制剂，在 pH 7.5 和 pH 9.5 时 K_i 值分别为 0.31 μM 和 30 nM。
生物活性	BEC hydrochloride is a slow-binding and competitive Arginase II inhibitor with K i of 0.31 μM and 30 nM at pH 7.5 and pH 9.5, respectively.
性状	Solid
IC50 & Target[1][2]	Ki: 0.31 μM (BEC hydrochloride, at pH 7.5) and 30 nM (BEC hydrochloride, at pH 9.5)
体外研究(In Vitro)	The X-ray crystal structure of the arginase-BEC complex has been determined at 2.3 ? resolution from crystals perfectly twinned by hemihedry. The structure of the complex reveals that the boronic acid moiety undergoes nucleophilic attack by metal-bridging hydroxide ion to yield a tetrahedral boronate anion that bridges the binuclear manganese cluster, thereby mimicking the tetrahedral intermediate (and its flanking transition states) in the arginine hydrolysis reaction. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Administration of the arginase inhibitor BEC decreases arginase activity and causes alterations in NO homeostasis, which are reflected by increases in S-nitrosylated and nitrated proteins in the lungs from inflamed mice. BEC enhances perivascular and peribronchiolar lung inflammation, mucus metaplasia, NF-κB DNA binding, and mRNA expression of the NF-κB-driven chemokine genes CCL20 and KC, and leads to further increases in airways hyperresponsiveness. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献	[1]. Colleluori DM, et al. Classical and slow-binding inhibitors of human type II arginase. Biochemistry. 2001 Aug 7;40(31):9356-62. [2]. Kim NN, et al. Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry. 2001 Mar 6;40(9):2678-88.

溶解度数据	In Vitro: H₂O : 125 mg/mL (544.69 mM; Need ultrasonic)DMSO : 50 mg/mL (217.87 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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