Ranolazine-d8 (dihydrochloride)|1219802-60-4|-陌孚医药/Medlife

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Ranolazine-d8 (dihydrochloride)

目录号: PL04710

CAS No. :1219802-60-4

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中文名称	Ranolazine-d8 (dihydrochloride)
中文别名	盐酸雷诺嗪-D8氘代内标;(±)-雷诺嗪-d82盐酸盐(哌嗪-d8);盐酸雷诺嗪-D8
英文名称	Ranolazine-d8 (dihydrochloride)
英文别名	(±)-Ranolazine-d8 2HCl (piperazine-d8);N-(2,6-dimethylphenyl)-2-[2,2,3,3,5,5,6,6-octadeuterio-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide,dihydrochloride;N-(2,6-Dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl](~2~H_8_)piperazin-1-yl}acetamide--hydrogen chloride (1/2);N-(2,6-Dimethylphenyl)-2-[2,2,3,3,5,5,6,6-octadeuterio-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piper
Cas No.	1219802-60-4
分子式	C₂₄H₃₅Cl₂N₃O₄
分子量	508.51
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情	Ranolazine-d₈ (dihydrochloride) 是 Ranolazine dihydrochloride 的氘代物。Ranolazine dihydrochloride (CVT 303 dihydrochloride) 是一种抗心绞痛和抗缺血剂，可通过抑制内向钠电流的后期作用 (对 I_Na 和 I_Kr 的 IC₅₀ 值分别为 6 μM 和 12 μM) 来发挥功效，而不会影响心率或血压。Ranolazine dihydrochloride 还是脂肪酸氧化的部分抑制剂。
生物活性	Ranolazine-d 8 (dihydrochloride) is the deuterium labeled Ranolazine dihydrochloride. Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[1][2]. Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor[3].
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Keating GM. Ranolazine: A Review of Its Use as Add-On Therapy in Patients with Chronic Stable Angina Pectoris. Drugs. 2013 Jan;73(1):55-73. [3]. Wang WQ, Robertson C, Dhalla

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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