Gallopamil hydrochloride|16662-46-7|(Methoxyverapamil hydrochloride)-陌孚医药/Medlife

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Gallopamil hydrochloride (Synonyms: Methoxyverapamil hydrochloride)

目录号: PL03983 纯度: ≥98%

CAS No. :16662-46-7

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中文名称	Gallopamil hydrochloride
中文别名	盐酸戈洛帕米
英文名称	Gallopamil hydrochloride
英文别名	5-((3,4-Dimethoxyphenethyl)(methyl)amino)-2-isopropyl-2-(3,4,5-trimethoxyphenyl)pentanenitrile hydrochloride;Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4,5-trimethoxy-a-(1-methylethyl)-, hydrochlori;METHOXYVERAPAMIL HYDROCHLORIDE;(+/-)-METHOXYVERAPAMIL HCL;(+/-)-METHOXYVERAPAMIL,HYDROCHLORIDE;(S)-Gallopamil;D 600 HYDROCHLORIDE;D600;D600,HCL;GALLOPAMIL;GALLOPAMIL HCL;GALLOPAMIL HYDROCHLORIDE
Cas No.	16662-46-7
分子式	C₂₈H₄₀N₂O₅^.HCl
分子量	521.09
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Gallopamil hydrochloride (Methoxyverapamil hydrochloride) 是一种维拉帕米的甲氧基衍生物 (methoxy derivative of verapamil)，也是一种苯基烷基胺钙 (phenylalkylamine calcium) 拮抗剂。Gallopamil hydrochloride 以浓度依赖性方式抑制酸分泌，IC₅₀ 为 10.9 μM。Gallopamil hydrochloride 是一种有效的抗心律不齐和血管扩张剂。

生物活性

Gallopamil hydrochloride (Methoxyverapamil hydrochloride), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist. Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC 50 of 10.9 μM. Gallopamil hydrochloride is a potent antiarrhythmic and vasodilator agent.

性状

Solid

体内研究(In Vivo)

Gallopamil hydrochloride (Methoxyverapamil hydrochloride; i.v.; 0.2 mg/kg; for 5 min) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF). Gallopamil significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate.
has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Brogden RN, et al. Gallopamil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in ischaemic heart disease. Drugs. 1994 Jan;47(1):93-115.
[2]. Sewing KF, et al. Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells. Pharmacology. 1983;27(1):9-14.

溶解度数据	In Vitro: DMSO : 100 mg/mL (191.91 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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