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Brivudine

(Synonyms: 溴夫定; Bromovinyldeoxyuridine; BVDU)

目录号: PL03505

Brivudine是具有抗病毒活性的胸苷类似物,用于早期急性带状疱疹的研究。

CAS No. :69304-47-8

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中文名称	Brivudine
中文别名	溴夫定;(E)-5-(2-溴乙烯基)-2'-脱氧核苷;(E)-5-(2-溴乙烯基)-2'-脱氧尿苷;(E)-5-(2-Bromovinyl)-2'-deoxyuridine (E)-5-(2-溴乙烯基)-2'-脱氧尿苷;3-(4-氟苯)-1H-吡唑-4-羧酸;溴比夫定;溴比夫定溴夫定;5-[(E)-2-溴乙烯基]-1-[(2R,4S,5R)-4-羟基-5-(羟甲基)氧杂环戊-2-基]嘧啶-2,4-二酮;溴乙烯尿苷
英文名称	Brivudine
英文别名	Brivudine;(E)-5-(2-bromovinyl)-2'-deoxyuridine;E-5-(2-BROMOVINYL)-2'-DEOXY-URIDINE;Uridine, 5-[(1E)-2-bromoethenyl]-2'-deoxy-;Bromovinyldeoxyuridine;BrVDU;BVDR;BVDU;5-[(E)-2-Bromoethenyl]-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione;Brivudin;Helpin;Zostex;Brivudine [INN];Brivudinum [INN-Latin];Brivudina [INN-Spanish];C11H13BrN2O5;5-(2-bromovinyl)-2'-deoxyuridine;(E)-5-(2-Bromovinyl)-deoxyuridine;Uridine, 5-(2-bromoethenyl)-2'-deoxy-, (E)-;trans-5-(2-Bromovinyl)-2'-deoxyuridine;Uridine, 5-(2-bromovinyl)-2'-deoxy-, (E)-;Brivudine (INN);5-BROMOVINYLD;BVdU
Cas No.	69304-47-8
分子式	C₁₁H₁₃BrN₂O₅
分子量	333.14
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	Brivudine是具有抗病毒活性的胸苷类似物,用于早期急性带状疱疹的研究。

产品详情

Brivudine是具有抗病毒活性的胸苷类似物,用于早期急性带状疱疹的研究。

生物活性

Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster.

性状

Solid

体外研究(In Vitro)

Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus compared with reference compounds such as aciclovir or penciclovir. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

At a dose of 125 mg once daily, brivudine has proved to be superior to aciclovir with respect to reducing the period of new blister production, and has shortened the duration of post-herpetic neuralgia. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Rabasseda X, et al. Brivudine: a herpes virostatic with rapid antiviral activity and once-daily dosing. Drugs Today (Barc). 2003 May;39(5):359-71.
[2]. Keam SJ, et al. Brivudin (bromovinyl deoxyuridine). Drugs. 2004;64(18):2091-7; discussion 2098-9.

溶解度数据	In Vitro: DMSO : 200 mg/mL (600.35 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Brivudine

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