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Retro-2

目录号: PL02540 纯度: ≥98%

Retro-2 是一种内体蛋白质-高尔基体逆行运输的选择性抑制剂。Retro-2 是一种埃博拉病毒 (EBOV) 感染抑制剂，在 HeLa 细胞中的EC50 为 12.2 µM。Retro-2 还可诱导细胞自噬 (autophagy)。

CAS No. :1201652-50-7

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中文名称	Retro-2
英文名称	Retro-2
英文别名	2-{[(5-methyl-2-thienyl)methylene]amino}-N-phenylbenzamide;2-[(5-methylthiophen-2-yl)methylideneamino]-N-phenylbenzamide;ARONIS017287;STK056997;ST029652;2-(((5-Methylthiophen-2-yl)methylene)amino)-n-phenylbenzamide;(e)-2-(((5-methylthiophen-2-yl)methylene)amino)-N-phenylbenzamide;{2-[(1E)-2-(5-methyl(2-thienyl))-1-azavinyl]phenyl}-N-benzamide;2-{[(E)-(5-methylthiophen-2-yl)methylidene]amino}-N-phenylbenzamide;30;Retro-2
Cas No.	1201652-50-7
分子式	C₁₉H₁₆N₂Os
分子量	320.41
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
详情描述	Retro-2 是一种内体蛋白质-高尔基体逆行运输的选择性抑制剂。Retro-2 是一种埃博拉病毒 (EBOV) 感染抑制剂，在 HeLa 细胞中的EC50 为 12.2 µM。Retro-2 还可诱导细胞自噬 (autophagy)。

产品详情	Retro-2 是一种内体蛋白质-高尔基体逆行运输的选择性抑制剂。Retro-2 是一种埃博拉病毒 (EBOV) 感染抑制剂，在 HeLa 细胞中的EC₅₀ 为 12.2 µM。Retro-2 还可诱导细胞自噬 (autophagy)。
生物活性	Retro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC 50 of 12.2 μM in HeLa cells. Retro-2 induces cell autophagy.
性状	Solid
IC50 & Target[1][2]	EC50: 12.2 μM (Ebolavirus)
体外研究(In Vitro)	Retro-2 (1 μM; 1-4 hours) induces autophagy in GFP-LC3-expressing HeLa cells and promoted the dramatic cytoplasmic accumulation of large autophagosomes. Retro-2 (1 μM; 0.5-4 hours) treatment hows an increase over time of the abundance of LC3-II protein in cells. Retro-2 impairs the trafficking between autophagosomes and lysosomes. Retro-2 abolishes autolysosomes formation. Retro-2 (20 μM; pretreatment for 30 min) inhibits HeLa cell intoxication by ricin, Shiga-like toxins 1 (Stx1) and 2 (Stx2). Retro-2 blocked invasion of cells by the intracellular parasite Leishmania , as well as replication of non-enveloped viruses, including polyoma-, papilloma-, and adeno-associated viruses. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Retro-2 (2-200 mg/kg; i.p; daily; for 21 days) treatment clearly protects from lethal nasal exposure to ricin in mice. 200 mg/kg of Retro-2 fully protects mice against ricin challenge. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Bahne Stechmann, et al. Inhibition of retrograde transport protects mice from lethal ricin challenge. Cell. 2010 Apr 16;141(2):231-42. [2]. Valérie Nicolas, et al. Small Trafficking Inhibitor Retro-2 Disrupts the Microtubule-Dependent Trafficking of Autophagic Vacuoles. Front Cell Dev Biol. 2020 Jun 18;8:464.

溶解度数据	In Vitro: DMSO : 250 mg/mL (780.25 mM; Need ultrasonic)配制储备液

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[1]. Bahne Stechmann, et al. Inhibition of retrograde transport protects mice from lethal ricin challenge. Cell. 2010 Apr 16;141(2):231-42.
[2]. Valérie Nicolas, et al. Small Trafficking Inhibitor Retro-2 Disrupts the Microtubule-Dependent Trafficking of Autophagic Vacuoles. Front Cell Dev Biol. 2020 Jun 18;8:464.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Retro-2

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