Sodium zirconium cyclosilicate|17141-74-1|-陌孚医药/Medlife

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Sodium zirconium cyclosilicate

目录号: PL02407

Sodium zirconium cyclosilicate 是一种口服、不吸收的新型无机微孔硅酸盐锆化合物，是一种高选择性阳离子交换剂，可选择性去除体内过量的 K⁺。Sodium zirconium cyclosilicate 可用于慢性肾脏疾病 (CKD) 的研究。

CAS No. :17141-74-1

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中文名称	Sodium zirconium cyclosilicate
英文名称	Sodium zirconium cyclosilicate
Cas No.	17141-74-1
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情

生物活性

Sodium zirconium cyclosilicate is an orally administered, non-absorbed, novel, inorganic microporous zirconium silicate compound, is a highly selective cation exchanger that selectively removes excess K in vivo. Sodium zirconium cyclosilicate can be used in research of chronic kidney disease (CKD).

体外研究(In Vitro)

Sodium zirconium cyclosilicate (ZS-9) is an inorganic cation exchange crystalline compound that has a high capacity to selectively entrap monovalent cations, specifically excess K and ammonium ions. Sodium zirconium cyclosilicate has the exchange capacities for the divalent ions Ca and Mg are below 0.05 mEq/g, and a >25-fold selectivity for K over either Ca or Mg. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Sodium zirconium cyclosilicate (ZS-9; 2-6 g/kg; p.o.; daily, for 5 d) is a recovery in feces of Sprague-Dawley rats and can efficient uptake and removal of potassium ions. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

ClinicalTrial

参考文献

[1]. Stavros F, et, al. Characterization of structure and function of ZS-9, a K+ selective ion trap. PLoS One. 2014 Dec 22;9(12):e114686.
[2]. Ash SR, et, al. A phase 2 study on the treatment of hyperkalemia in patients with chronic kidney disease suggests that the selective potassium trap, ZS-9, is safe and efficient. Kidney Int. 2015 Aug;88(2):404-11.

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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