UTL-5g|646530-37-2|(GBL-5g)-陌孚医药/Medlife

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UTL-5g (Synonyms: GBL-5g)

目录号: PL02325 纯度: ≥98%

CAS No. :646530-37-2

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PL02325-10mM*1mLinDMSO	10mM*1mLinDMSO	¥4420.00	请登录

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中文名称	UTL-5g
英文名称	UTL-5g
英文别名	3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-;N-(2,4-dichlorophenyl)-5-methyl-1,2-oxazole-3-carboxamide;UTL-5g
Cas No.	646530-37-2
分子式	C₁₁H₈Cl₂N₂O₂
分子量	271.10
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	UTL-5g (GBL-5g) 是一种抗炎性 TNF-α 抑制剂，具有化学保护和肝脏放射保护作用。UTL-5g 通过抑制 TNF-α 等因子降低顺铂引起的肝毒性、肾毒性和骨髓毒性。
生物活性	UTL-5g (GBL-5g), an anti-inflammatory TNF-α inhibitor, has chemoprotective and liver radioprotective effects. UTL-5g lowers hepatotoxicity, nephrotoxicity, and myelotoxicity induced by Cisplatin through TNF-α inhibition among other factors.
性状	Solid
体外研究(In Vitro)	RAW 264.7 macrophages are transfected with the respective reporter assay plasmids, pretreated with UTL-5g at 1, 10 or 50 μM for 60 min and then challenged with 100 ng/ml LPS. After a 16 h incubation, transcription factor activity is measured. Transcription factors that shows a UTL-5g dose-dependent decrease in activity in two experiments are categorized as being disrupted by UTL-5g. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	UTL-5g (GBL-5g) lowers levels of TGF-β and TNF-α elevated by lung irradiation. UTL-5g (60 mg/kg; p.o.; daily for 4 days) shows positive effects in increasing the survival rates and extending the survival times. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Stephen Brown, et al. UTL-5g Lowers Levels of TGF-β and TNF-α Elevated by Lung Irradiation [2]. Carruthers NJ, et al. Phosphoproteome and transcription factor activity profiling identify actions of the anti-inflammatory agent UTL-5g in LPS stimulated RAW 264.7 cells including disrupting actin remodeling and STAT-3 activation. Eur J Pharmacol. 2017;8

溶解度数据	In Vitro: DMSO : 100 mg/mL (368.87 mM; Need ultrasonic)配制储备液

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