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(2R/S)-6-PNG

(Synonyms: 6-Prenylnaringenin; (±)-6-Prenylnaringenin)

目录号: PL02272 纯度: ≥99%

(2R/S)-6-PNG (6-Prenylnaringenin) 是一种有效且可逆的 Cav3.2 T 型 Ca²⁺ 通道 (T 通道)阻滞剂。(2R/S)-6-PNG 可以透过血脑屏障 (BBB)。(2R/S)-6-PNG 抑制小鼠的神经性和内脏疼痛。

CAS No. :68682-01-9

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PL02272-10mg	10mg	¥7393.00	请登录
PL02272-25mg	25mg	¥14786.00	请登录
PL02272-50mg	50mg	¥23787.00	请登录
PL02272-100mg	100mg	询价	询价
PL02272-200mg	200mg	询价	询价

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中文名称	(2R/S)-6-PNG
英文名称	(2R/S)-6-PNG
英文别名	(卤)-4',5,7-Trihydroxy-6-prenylflavanone;(S)-4',5,7-Trihydroxy-6-prenylflavanone;5,7,4'-trihydroxy-6-prenylflavanone;5,7-dihydroxy-2-(4-hydroxy-phenyl)-6-(3-methyl-but-2-enyl)-chroman-4-one;6-C-prenylnaringenin;6-PN;6-prenylnaringenin;rac-6-Prenylnaringenin;sophoraflavanone B;sophoraflavone B;(2R/S)-6-PNG;6PNG;6-PNG;MLS000863575;5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one;SMR000440733;K 07047;2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one;6 PNG; 6-PNG;MEGxp0_001752;BDBM58016;cid_3519901;HMS2271K08;BCP31580;4',5,7-Trihydroxy-6-prenylflavanone;HY-1
Cas No.	68682-01-9
分子式	C₂₀H₂₀O₅
分子量	340.37
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months
详情描述	(2R/S)-6-PNG (6-Prenylnaringenin) 是一种有效且可逆的 Cav3.2 T 型 Ca²⁺ 通道 (T 通道)阻滞剂。(2R/S)-6-PNG 可以透过血脑屏障 (BBB)。(2R/S)-6-PNG 抑制小鼠的神经性和内脏疼痛。

产品详情

(2R/S)-6-PNG (6-Prenylnaringenin) 是一种有效且可逆的 Ca_v3.2 T 型 Ca²⁺ 通道 (T 通道)阻滞剂。(2R/S)-6-PNG 可以透过血脑屏障 (BBB)。(2R/S)-6-PNG 抑制小鼠的神经性和内脏疼痛。

生物活性

(2R/S)-6-PNG (6-Prenylnaringenin) is a potent and reversible Ca v 3.2 T-type Ca channels (T-channels) blocker. (2R/S)-6-PNG can penetrate the blood-brain barrier (BBB). (2R/S)-6-PNG suppresses neuropathic and visceral pain in mice.

性状

Solid

IC50 & Target[1][2]

T-type calcium channel

体外研究(In Vitro)

(2R/S)-6-PNG (6-Prenylnaringenin) potently blocks Cav3.2, but exhibits minor effect on high-voltage-activated Ca channels and voltage-gated Na channels in differentiated NG108-15 cells.
On the basis of IC50 values, the proportion (Cav3.2/HVA) of the inhibition potency of (2R/S)-6-PNG on Cav3.2 and HVA-currents is 5.20, and that (Cav3.2/Nav) on Cav3.2 and Nav-currents is 3.54.
has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

(2R/S)-6-PNG (6-Prenylnaringenin; 10-30 mg/kg; i.p.; single dose; 15 min before Na2S) significantly reduced the Na 2 S-induced nociceptive behavior and/or referred hyperalgesia in onscious mice with intracolonic (i.col.) administration of Na 2 S, an H 2 S donor.
(2R/S)-6-PNG (30 mg/kg; i.p.) prevents the increased number of phosphorylated ERK-positive cells following i.col. Na2S in laminae I-II, V-VI and X to which the primary afferent neurons project, and the Na2S-induced increase in the phosphorylated ERK-positive cell number.
(2R/S)-6-PNG (0.01-1 and 0.1-10 nmol/paw; intraplantar administration) restores the mechanical allodynia induced by partial sciatic nerve ligation (PSNL) and by i.p. administration of Oxaliplatin (OHP) a, respectively, in a dose-dependent manner.
(2R/S)-6-PNG (20-30 mg/kg; i.p.) significantly reverses the PSNL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；In solvent -80°C 6 months

ClinicalTrial

参考文献

[1]. Fumiko Sekiguchi, et al. Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in mice. Neuropharmacology

溶解度数据	In Vitro: DMSO : 125 mg/mL (367.25 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

[1]. Fumiko Sekiguchi, et al. Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in mice. Neuropharmacology

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

(2R/S)-6-PNG

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