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| 商品编号 | 规格 | 价格 | 会员价 | 是否有货 | 数量 |
|---|---|---|---|---|---|
| PL02234-100mg | 100mg | ¥243.00 | 请登录 |
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| PL02234-200mg | 200mg | 询价 | 询价 |
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| PL02234-500mg | 500mg | ¥583.00 | 请登录 |
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| PL02234-10mM*1mLinDMSO | 10mM*1mLinDMSO | ¥884.00 | 请登录 |
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| PL02234-1 mL x 10 mM (in DMSO) | ¥268.00 | 请登录 |
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| 中文名称 |
Benproperine phosphate
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|---|---|
| 中文别名 |
磷酸苯丙哌林;1-[2-(2-苄基苯氧基)-1-甲基乙基]哌啶磷酸盐;咳快好（磷酸苯丙哌林）;磷酸苯丙哌啉;N-(2,3-二氢-1H-茚-2-基)-2,2,2-三氟乙酰胺;磷酸苯丙哌林溶液,100PPM;磷酸苯丙哌林原药粉生产厂家行情价格;磷酸苯丙哌啉 100MG
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| 英文名称 |
Benproperine phosphate
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| 英文别名 |
benproperine phosphate;1-[2-(2-Benzylphenoxy)-1-methylethyl]piperidine phosphate;Flaveric;Blascorid;ASA 158-5;Benproperine phospha;Trihydrogen phosphate;Benproperine Phosphater;BENPROPERINE PHOSPHATE CP2000;Benproperine phosphate Solution, 100ppm;1-[1-(2-benzylphenoxy)propan-2-yl]piperidine;磷酸苯丙哌林原药粉生产厂家行情价格;Pirexyl phosphate;Pirexyl;Benproperine trihydrogen phosphate;Benproperine phosphate [JAN];1-(1-Methyl-2-(2-benzylphenoxy)ethyl)piperidine phosphate;1-(2-Benzylphenoxy)-2-piperidinopropane phosphate;CPD000469294;1-(2-(2-Benzilfenossi)-1-metiletil)-piperidina fosfato [Italian];1-(1-Methyl-2-((alpha-phenyl-o-tolyl)oxy)ethyl)piperidine phosphate;Benproperine phosphate (JAN);1-(2-(2-Benzylphenoxy)-1-methylethyl)piperidinium dihydr
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| Cas No. |
19428-14-9
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| 分子式 |
C21H30NO5P
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| 分子量 |
407.44
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| 包装储存 |
4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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| 详情描述 |
Benproperine phosphate 是一种具有口服活性的，有效的肌动蛋白相关蛋白 2/3 复合亚基 2 (ARPC2) 抑制剂。Benproperine phosphate 通过削弱 Arp2/3 功能来减弱肌动蛋白的聚合反应速率。Benproperine phosphate 有潜力用于止咳，并可以抑制癌细胞迁移和肿瘤转移。
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| 产品详情 |
Benproperine phosphate 是一种具有口服活性的，有效的肌动蛋白相关蛋白 2/3 复合亚基 2 (ARPC2) 抑制剂。Benproperine phosphate 通过削弱 Arp2/3 功能来减弱肌动蛋白的聚合反应速率。Benproperine phosphate 有潜力用于止咳，并可以抑制癌细胞迁移和肿瘤转移。
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| 生物活性 |
Benproperine phosphate is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate has the potential for a cough suppressant and suppresses cancer cell migration and tumor metastasis.
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| 性状 |
Solid
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| 体外研究(In Vitro) |
Benproperine phosphate (20-120 μM; for 24?hours) inhibits cell viability in a dose-dependent manner. Benproperine phosphate (10 μM; for 24?hours) significantly inhibits the migration of various types of cancer cells and inhibits the migration and invasion of DLD-1, AsPC-1 cells with IC50 values of 1-2?μM. Benproperine phosphate (10 μM; for 24?hours) does not affect cortactin-rich lamellipodium in MCF-10A cells. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 体内研究(In Vivo) |
Benproperine phosphate (50, 100?mg/kg; oral gavage; 5?days per week for 4?weeks) inhibits primary pancreatic tumor growth.
Benproperine phosphate shows a marked decrease in the lung metastasis of AsPC-1 cells (56.1% inhibition) in mouse. Benproperine phosphate significantly suppressed the liver metastasis of HCT-116 cells by 78.9% and DLD-1 cells by 78.2%. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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| 参考文献 |
[1]. Yae Jin Yoon, et al. Benproperine, an ARPC2 inhibitor, suppresses cancer cell migration and tumor metastasis. Biochem Pharmacol. 2019 May;163:46-59.
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| 溶解度数据 |
In Vitro: DMSO : 250 mg/mL (613.59 mM; Need ultrasonic)H2O : ≥ 100 mg/mL (245.43 mM)
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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