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HC-056456

(Synonyms: 3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide)

目录号: PL02097 纯度: ≥98%

HC-056456 是一种有效但不完全选择性的 CatSper 通道阻断剂。HC-056456 减慢 [Na⁺]i 上升，IC50 为 3 µM。

CAS No. :7733-96-2

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PL02097-1 mL x 10 mM (in DMSO)		¥738.00	请登录

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中文名称	HC-056456
英文名称	HC-056456
英文别名	[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone
Cas No.	7733-96-2
分子式	C₁₂H₆N₂O₄S₂
分子量	306.32
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	HC-056456 是一种有效但不完全选择性的 CatSper 通道阻断剂。HC-056456 减慢 [Na⁺]i 上升，IC50 为 3 µM。

产品详情	HC-056456 是一种有效但不完全选择性的 CatSper 通道阻断剂。HC-056456 减慢 [Na⁺]_i 上升，IC₅₀ 为 3 µM。
生物活性	HC-056456 is an effective but not perfectly-selective blocker of CatSper channels. The [Na] i rise is slowed by HC-056456 (IC 50 ~3 μM).
性状	Solid
IC50 & Target[1][2]	CatSper
体外研究(In Vitro)	HC-056456 similarly slows the rise of [Ca]i that is evoked by alkaline depolarization and reported by fura-2. HC-056456 also selectively and reversibly decreased CatSper currents recorded from patch-clamped sperm. HC-056456 produces a pharmacological phenocopy of the CatSper-null sperm. Acute application of HC-056456 causes rapid loss of flagellar waveform asymmetry from hyperactivated sperm, indicating that continued entry of Ca through CatSper channels is required to maintain hyperactivation. HC-056456 selectively and reversibly blocks CatSper currents. The specificity and reversibility of the blockade of CatSper-dependent currents by HC-056456 is examined by using patch clamp recordings. The observed current is blocked slightly more than 50% by 20 μM HC-056456 (estimated IC50 near 15 μM). In concept, it remains possible that CatSper channel heterogenei
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Carlson AE, et al. Pharmacological targeting of native CatSper channels reveals a required role in maintenance of sperm hyperactivation. PLoS One. 2009 Aug 31;4(8):e6844.

溶解度数据	In Vitro: DMSO : 125 mg/mL (408.07 mM; Need ultrasonic)配制储备液

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[1]. Carlson AE, et al. Pharmacological targeting of native CatSper channels reveals a required role in maintenance of sperm hyperactivation. PLoS One. 2009 Aug 31;4(8):e6844.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

HC-056456

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