CORM-401 是一种对氧化剂敏感的 CO 释放分子。CORM-401 诱导内皮钙信号调节中的 NO 增加。CORM-401 减少 TNF-α/CHX 和 H2O2 诱导的 ROS 产生。CORM-401 解耦线粒体呼吸并抑制糖酵解。

CORM-401 is an oxidant-sensitive CO-releasing molecule. CORM-401 induces NO increase in the regulation of endothelial calcium signalling. CORM-401 reduces TNF-α/CHX and H2O2-induced ROS production. CORM-401 uncouples mitochondrial respiration and inhibits glycolysis.

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CORM-401 (100 μM; 1h) induces the NO production in endothelial EA.hy926 cells.
CORM-401 (30 μM) induces peak-like calcium signal and augmentes coupling of endoplasmic reticulum and plasmalemmal store-operated calcium channels.
CORM-401 (50 μM; 1h) significantly reduces TNF-α/CHX and H2O2-induced ROS production and cell death.
CORM-401 (0.5, 1 mM) induces a persistent increase in the oxygen consumption rate in endothelial EA.hy926 cells.
CORM-401 (10, 30, 100 μM) induces a concentration-dependent increase in OCR and a simultaneous decrease in ECAR. has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；In solvent -80°C 6 months

[1]. Kaczara P, et al. CORM-401 induces calcium signalling, NO increase and activation of pentose phosphate pathway in endothelial cells. FEBS J. 2018 Apr;285(7):1346-1358.
[2]. Babu D, et al. Differential Effects of CORM-2 and CORM-401 in Murine Intestinal Epithelial MODE-K Cells under Oxidative Stress. Front Pharmacol. 2017 Feb 8;8:31.

In Vitro: DMSO : 25 mg/mL (75.48 mM; Need ultrasonic)配制储备液