Estrogen receptor modulator 1|63676-22-2|-陌孚医药/Medlife

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Estrogen receptor modulator 1

目录号: PL01831 纯度: ≥99%

Estrogen receptor modulator 1 (compound 18) 是一种口服活性选择性雌激素受体 (estrogen receptor) 调节剂 (SERM)，pIC50 为 0.46。Estrogen receptor modulator 1 诱导 Tamoxifen 耐药、激素非依赖性异种移植瘤的消退。

CAS No. :63676-22-2

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中文名称	Estrogen receptor modulator 1
中文别名	2-(4-羟苯基)-苯并[b]噻吩-6-醇;2-(4-羟基苯基)-苯并[b]噻吩-6-醇;2-(4-羟基苯基)苯并[B]噻吩-6-醇;雷洛昔芬杂质2;i>]噻吩-6-醇;雷洛昔芬杂质;2-(4-羟基苯基)苯并[b]噻吩-6-醇
英文名称	Estrogen receptor modulator 1
英文别名	2-(4-Hydroxyphenyl)benzo[b]thiophen-6-ol;2-(4-Hydroxyphenyl)benzo[b]thiophene-6-ol;6-HYDROXY-2-(4-HYDROXYPHENYL) BENZO (B) THIOPHENE;BTC;2-(4-hydroxyphenyl)-6-hydroxybenzo[b]thiophene;2-(4-HYDROXYPHENYL)-BENZO[B]THIOPHENE-6-OL;6-hydroxy-2-(4-hydroxyphenyl)benzo< b> thiophene;AC1L9IS0;AG-G-36761;benzthiophene compound, 3;RALOXIFENE CORE;SureCN2567321;ZTW;2-(4-Hydroxyphenyl)-1-benzothiophene-6-ol;2-(4-hydroxyphenyl)-1-benzothiophen-6-ol;Benzo[b]thiophene-6-ol, 2-(4-hydroxyphenyl)-;6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene;BDBM20628;MDGWZLQPNOETLH-UHFFFAOYSA-N;EBD47226;Estrogen receptor modulator 1
Cas No.	63676-22-2
分子式	C₁₄H₁₀O₂S
分子量	242.29
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months

产品详情	Estrogen receptor modulator 1 (compound 18) 是一种口服活性选择性雌激素受体 (estrogen receptor) 调节剂 (SERM)，pIC₅₀ 为 0.46。Estrogen receptor modulator 1 诱导 Tamoxifen 耐药、激素非依赖性异种移植瘤的消退。
生物活性	Estrogen receptor modulator 1 (compound 18) is an orally active and selective estrogen receptor modulator (SERM), with a pIC 50 of 0.46. Estrogen receptor modulator 1 induces regression of Tamoxifen-resistant, hormone independent xenograft tumors.
性状	Solid
体外研究(In Vitro)	Estrogen receptor modulator 1 (compound 18) (100 nM; 10 days) inhibits T47D:A18/PKCα and T47D:A18-TAM1 colony formation. Estrogen receptor modulator 1 (100 nM; 9 days) significantly inhibits the growth of MCF-7:5C cell, and induces apoptosis in these cells 6 days. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Proliferation Assay
体内研究(In Vivo)	Estrogen receptor modulator 1 (1.5 mg/animal; p.o. ; daily for 2 weeks) results in regression of T47D:A18/PKCα tumors. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 4-6 week old ath
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；In solvent -80°C 6 months
参考文献	[1]. Brogi S, et al. 3D-QSAR using pharmacophore-based alignment and virtual screening for discovery of novel MCF-7 cell line inhibitors. Eur J Med Chem. 2013 Sep;67:344-51. [2]. Molloy ME, et al. Novel selective estrogen mimics for the treatment of tamoxifen-resistant breast cancer. Mol Cancer Ther. 2014 Nov;13(11):2515-26.

溶解度数据	In Vitro: DMSO : 100 mg/mL (412.73 mM; Need ultrasonic)配制储备液

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