LY309887|127228-54-0|-陌孚医药/Medlife

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LY309887

目录号: PL01652 纯度: ≥98%

CAS No. :127228-54-0

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中文名称	LY309887
英文名称	LY309887
英文别名	L-Glutamic acid,N-[[5-[2-[(6R)-2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]-2-thienyl]carbonyl]-;LY309887;N-[(5-{2-[(6R)-2-Amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]py rimidin-6-yl]ethyl}-2-thienyl)carbonyl]-L-glutamic acid;Garft II;L-Glutamic acid,N-[[5-[2-[(6R)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]-2-thienyl]carbonyl]-(9CI);L-Glutamicacid, N-[[5-[2-(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl)ethyl]-2-thienyl]carbonyl]-,(R)-;Pyrido[2,3-d]pyrimidine, L-glutamic acid deriv.
Cas No.	127228-54-0
分子式	C₁₉H₂₃N₅O₆S
分子量	449.48
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	LY309887 是一种有效的二氢叶酸还原酶 (GARFT) 抑制剂，K_i 值为 6.5 nM，具有抗肿瘤活性。
生物活性	LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a K i of 6.5 nM, and has antitumor activity.
性状	Solid
IC50 & Target[1][2]	Ki: 6.5 nM (GARFT), 1.78 nM (Folate receptor α), 18.2 nM (Folate receptor β)
体外研究(In Vitro)	LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 6.5 nM for human GARFT and also has high affinity at human folate receptor (FR)α and FRβ (Ki, 1.78 nM and 18.2 nM, respectively). LY309887 is signigicantly cytotoxic against the human leukemia cell line CCRF-CEM with IC50 of 9.9 nM. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	LY309887 (3 mg/kg-100 mg/kg, i.p.) shows complete inhibition on the tumor growth in mice bearing C3H mammary cancer cells. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Mendelsohn LG, et al. Biochemistry and pharmacology of glycinamide ribonucleotide formyltransferase inhibitors: LY309887 and lometrexol. Invest New Drugs. 1996;14(3):287-94.

搜索质检报告(COA)

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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