Thalidomide-O-amido-C4-NH2 hydrochloride|2245697-86-1|-陌孚医药/Medlife

您当前的位置：

Thalidomide-O-amido-C4-NH2 hydrochloride

目录号: PL01611 纯度: ≥98%

CAS No. :2245697-86-1

商品编号	规格	价格	会员价
PL01611-25mg	25mg	¥1928.00	请登录
PL01611-100mg	100mg	¥5625.00	请登录
PL01611-200mg	200mg	询价	询价
PL01611-500mg	500mg	询价	询价

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Thalidomide-O-amido-C4-NH2 hydrochloride
英文名称	Thalidomide-O-amido-C4-NH2 hydrochloride
英文别名	Thalidomide-O-amido-C4-NH2 hydrochloride;Thalidomide-O-amido-C4-NH2 (hydrochloride);N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide hydrochloride;Thalidomide - linker 3;BCP33445;Thalidomide 4'-oxyacetamide-alkylC4-amine;Thalidomide-linker 3;Thalidomide 4'-oxyacetamide-alkylC4-amine;N-(4-Aminobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochl
Cas No.	2245697-86-1
分子式	C₁₉H₂₃ClN₄O₆
分子量	438.86
包装储存	-20°C, stored under nitrogen, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

产品详情	Thalidomide-O-amido-C4-NH2 hydrochloride 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 1 个 linker。可用于合成 PROTAC 分子。
生物活性	Thalidomide-O-amido-C4-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.
性状	Solid
IC50 & Target[1][2]	Cereblon
体外研究(In Vitro)	Thalidomide-O-amido-C4-NH2 is an amine intermediate (Compound 41), which can be used as is a heterobifunctional PROTAC BET degrader. The bromodomain and extra-terminal (BET) family proteins, consisting of BRD2, BRD3, BRD4, and testis-specific BRDT members, are epigenetic “readers” and play a key role in the regulation of gene transcription. BET proteins are considered to be attractive therapeutic targets for cancer and other human diseases. Recently, heterobifunctional small-molecule BET degraders have been designed based upon the proteolysis targeting chimera (PROTAC) concept to induce BET protein degradation. Thalidomide-O-amido-C4-NH2 is a degron-linker (refer to Compound DL6-TL). Degron-linker-targeting ligand, wherein the linker is covalently bound lo at least one degron and at least one targeting ligand, the degron is a compound capable of binding to an ubiquitin
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, stored under nitrogen, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
参考文献	[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression.J Med Chem. 2018 Jan 25;61(2):462-481. [2]. James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.

溶解度数据	In Vitro: DMSO : 250 mg/mL (569.66 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation