WIN 54954|107355-45-3|-陌孚医药/Medlife

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WIN 54954

目录号: PL01558 纯度: ≥98%

CAS No. :107355-45-3

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中文名称	WIN 54954
英文名称	WIN 54954
英文别名	Isoxazole,5-[5-[2,6-dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy]pentyl]-3-methyl-;5-{5-[2,6-Dichloro-4-(1,3-oxazol-2-yl)phenoxy]pentyl}-3-methyl-1,2-oxazole;isoxazole, 5-[5-[2,6-dichloro-4-(2-oxazolyl)phenoxy]pentyl]-3-methyl-;WIN 54954
Cas No.	107355-45-3
分子式	C₁₈H₂₀N₂O₃Cl₂
分子量	383.27
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	WIN 54954 是一种口服有效的广谱抗小核糖核酸病毒剂。WIN 54954 对人鼻病毒、埃可病毒 9 和肠道病毒感染有效。
生物活性	WIN 54954 is an orally active and broad-spectrum antipicornavirus agent. WIN 54954 is effectiveness against human rhinovirus, echovirus 9 and enterovirus infections.
性状	Solid
体外研究(In Vitro)	WIN 54954 reduces plaque formation of 50 of 52 rhinovirus serotypes (MICs ranges from 0.007 to 2.2 μg/mL).WIN 54954 inhibits 15 commonly isolated enteroviruses, with an EC80 of 0.06 μg/mL. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	WIN 54954 (2-100 mg/kg; p.o.) protects 50% of the mice from developing paralysis following infection with coxsackievirus A-9 and echovirus-9 at the dose of 2 and 100 mg/kg, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Woods MG, et, al. In vitro and in vivo activities of WIN 54954, a new broad-spectrum antipicornavirus drug. Antimicrob Agents Chemother. 1989 Dec;33(12):2069-74. [2]. Fechner H, et, al. Pharmacological and biological antiviral therapeutics for cardiac coxsackievirus infections. Molecules. 2011 Oct 11;16(10):8475-503.

溶解度数据	In Vitro: DMSO : 100 mg/mL (260.91 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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