Larazotide acetate|881851-50-9|(醋酸拉瑞唑来)-陌孚医药/Medlife

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Larazotide acetate (Synonyms: 醋酸拉瑞唑来)

目录号: PL01557 纯度: ≥98%

CAS No. :881851-50-9

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中文名称	Larazotide acetate
中文别名	acetic acid,2-[[(2S)-1-[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-5-oxopentan;醋酸拉瑞唑来
英文名称	Larazotide acetate
英文别名	acetic acid,2-[[(2S)-1-[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]acetic acid;Larazotide acetate;Larazotide (acetate);Larazotide acetate [USAN];Larazotide acetate (USAN);Glycine, glycylglycyl-L-valyl-L-leucyl-L-valyl-L-glutaminyl-L-prolyl-, monoacetate;FO8S2IW40N;A16916;D09352;Q25327025;Glycylglycyl-L-valyl-L-leucyl-L-valyl-L-glutaminyl-L-prolylglycine acetate
Cas No.	881851-50-9
分子式	C₃₄H₅₉N₉O₁₂
分子量	785.89
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情

Larazotide acetate 是一种多肽，是具有口服活性的 zonulin 拮抗剂。Larazotide acetate 对水痘带状疱疹病毒 (VZV) 具有抗病毒活性，对 OKA 和 07-1 株系的 EC₅₀ 值分别为 44.14 和 59.06 μM。Larazotide acetate 可用于乳糜泻和感染的研究。

生物活性

Larazotide acetate is a peptide which is an orally active zonulin antagonist. Larazotide acetate shows antiviral activity to varicella-zoster virus (VZV) with EC 50 s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide acetate can be used for the research of celiac disease and infection.

性状

Solid

IC50 & Target[1][2]

Paracellular permeability

体外研究(In Vitro)

Larazotide acetate (1-100 μM; 5 d) affects Vero cell growth.
Larazotide acetate (1-100 μM; 3 d) shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively.
Larazotide acetate (1 and 3 mM; 72 h) inhibits cytokine-induced tight junction permeability in Caco-2 cells.
Larazotide acetate (12.5 mM; 1 h) inhibits PTG-induced ZO-1 redistribution and actin cytoskeletal rearrangement in IEC6 cells. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Larazotide acetate (250 μg; i.p. twice a week for 7 weeks) inhibits intestinal permeability in gluten-sensitive transgenic mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: HLA-HC

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

ClinicalTrial

参考文献

[1]. Di Micco S, et al. Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation. Int J Mol Sci. 2021 Aug 30;22(17):9427.
[2]. Gopalakrishnan S, et al. Larazotide acetate regulates epithelial tight junctions in vitro and in vivo. Peptides. 2012 May;35(1):86-94.

溶解度数据	In Vitro: H₂O : 16.67 mg/mL (21.21 mM; Need ultrasonic)DMSO : 3.2 mg/mL (4.07 mM; Need ultrasonic and warming)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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