Forigerimod TFA (IPP-201101 TFA) is a CD4 T-cell modulator. Forigerimod TFA is a 21-amino-acid fragment of U1 small nuclear ribonucleoprotein 70 kDa that is phosphorylated at Ser140. Forigerimod TFA can potently inhibit autophagy. Forigerimod can be used for the research of autoimmune disorders, such as systemic lupus erythematosus (SLE) .
性状
Solid
体内研究(In Vivo)
Forigerimod TFA (P140) (i.v.; 100 μg in 100 μL saline per mouse) 直接作用于分子伴侣介导的自噬,使 MRL/lpr 小鼠免于唾液腺中发生的细胞浸润和自噬缺陷。 has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model: MRL/lpr mice
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years;-20°C 1 ye
SequenceShortening
RIHMVYSKR-{Ser-phosphono}-GKPRGYAFIEY (TFA)
参考文献
[1]. Aikaterini Thanou, et al. Treatment of systemic lupus erythematosus: new therapeutic avenues and blind alleys. [2]. Sean Robinson, et al. Potential for Antigen-Specific Tolerizing Immunotherapy in Systematic Lupus Erythematosus. Front Immunol. 2021 Jul 16;12:654701.[3]. Robert Zimmer, et al. Lupuzor/P140 pept
溶解度数据
In Vitro: H2O : 100 mg/mL (36.32 mM; Need ultrasonic)配制储备液
[1]. Aikaterini Thanou, et al. Treatment of systemic lupus erythematosus: new therapeutic avenues and blind alleys. [2]. Sean Robinson, et al. Potential for Antigen-Specific Tolerizing Immunotherapy in Systematic Lupus Erythematosus. Front Immunol. 2021 Jul 16;12:654701.[3]. Robert Zimmer, et al. Lupuzor/P140 pept