TP-024|1358575-02-6|(FTBMT)-陌孚医药/Medlife

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TP-024 (Synonyms: FTBMT)

目录号: PL01284 纯度: ≥99%

CAS No. :1358575-02-6

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中文名称	TP-024
英文名称	TP-024
英文别名	FTBMT;4-(3-(3-Fluoro-5-(trifluoromethyl)benzyl)-5-methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide;4-[3-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1,2,4-triazol-1-yl]-2-methylbenzamide;BCP29255;BDBM50252092;J3.639.833G;2-Methyl-4-[3-[3-fluoro-5-(trifluoromethyl)benzyl]-5-methyl-1H-1,2,4-triazole-1-yl]benzamide;4-[3-[[3-Fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1H-1,2,4-triazol-1-yl]-2-methylbenzamide
Cas No.	1358575-02-6
分子式	C₁₉H₁₆F₄N₄O
分子量	392.35
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	TP-024 (FTBMT) 是选择性的 GPR52 激动剂， EC₅₀ 为 75 nM。TP-024 有抗精神病和促进认知活性。
生物活性	TP-024 (FTBMT) is a selective GPR52 agonist with an EC 50 of 75 nM. TP-024 has antipsychotic and procognitive properties.
性状	Solid
IC50 & Target[1][2]	IC50: 75 nM (GPR52)
体外研究(In Vitro)	TP-024 (FTBMT) (0.1-10 μM) increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50s of 7.03, 6.85, and 6.87, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay
体内研究(In Vivo)	TP-024 (FTBMT) (30 mg/kg, 90 minutes) exhibits antipsychotic-like activity without causing catalepsy in mice. TP-024 (3 or 10 mg/kg, 48 hours) improves recognition and spatial working memory in rats. TP-024 (3, 10, 30 mg/kg, 2 hours) stimulates neuronal activity in brain regions related to cognition. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Tokumaru K, et al. Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists. Bioorg Med Chem. 2017 Jun 15;25(12):3098-3115. [2]. Nishiyama K, et al. FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia. J Pharmacol Exp Ther. 2017 Nov;363(2):253-264.

溶解度数据	In Vitro: DMSO : 50 mg/mL (127.44 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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