Trametinib

盐酸法舒地尔;六氢-1-(5-异喹啉磺酰基)-1H-1,4-二氮杂卓盐酸盐;Fasudil Hydrochloride 盐酸法舒地尔;Fasudil hydrochloride 抑制剂;盐酸法苏地尔;(5-异喹啉磺酰基)高哌嗪盐酸盐;5-(1-高哌嗪)磺酰基异喹啉盐酸盐

Trametinib (GSK1120212)

1-(5-ISOQUINOLINESULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE, DIHYDROCHLORIDE;1-(5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE 2HCL;1-(5-ISOQUINOLINESULFONYL)-HOMOPIPERAZINE DIHYDROCHLORIDE;1-(5-ISOQUINOLINESULFONYL)-HOMOPIPERAZINE HCL;1-(5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE HYDROCHLORIDE;1-(5-ISOQUINOLINYLSULFONYL)HOMOPIPERAZINE DIHYDROCHLORIDE;5-(1,4-DIAZEPAN-1-YLSULFONYL)ISOQUINOLINE HYDROCHLORIDE;(5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE, 2HCL;FASUDEL;FASUDIL DIHYDROCHLORIDE;FASUDIL HCL;FASUDIL HYDROCHLORIDE;HA-1077;HA-1077 DIHYDROCHLORIDE;HEXAHYDRO-1-(5-ISOQUINOLINYLSULFONYL)-MONOHYDROCHLORIDE;Fasudil Monohydrochloride Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine monohydrochloride;4-Methoxyphenylacetic acid;5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride;FASUDIL;Fasudil (HA-1077) HCl;Fasudil (Hydrochloride);Fasudil Monohydrochloride;5-(1-Homopiperazinyl)sulfonylisoquinoline Hydrochloride;AT-877;Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine monohydrochloride;Eril;AT 877 hydrochloride;HA 1077 hydrochloride;SQ04N8S7BR;DSSTox_RID_81004;DSSTox_CID_25615;DSSTox_GSID_45615;C14H18ClN3O2S;1H-1,;C14H17N3O2S.HCl;1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-, monohydrochloride

871700-17-3

C₂₆H₂₃FIn₅O₄

615.39

Trametinib(GSK1120212; JTP-74057)是口服有效的MEK抑制剂，抑制MEK1和MEK2的IC50分别为2 nM。Trametinib可以激活自噬(autophagy)，诱导凋亡(apoptosis)，可透过血脑屏障(BBB)，用于蛛网膜下腔出血(SAH)相关研究。