SB431542

2-甲基-2-[4-[3-甲基-2-氧代-8-(喹啉-3-基)-2,3-二氢咪唑并[4,5-c]喹啉-1-基]苯基]丙腈;17-羟基-3-氧代孕甾-4,6,9-三烯-21-羧酸 GAMMA-内酯;BEZ235(NVP-BEZ235) 抑制剂;苯乙氰, 4-[2,3-二氢-3-甲基-2-氧代-8-(3-喹啉基)-1H-咪唑并[4,5-c]喹啉-1-基]-.alpha.,.alpha.-二甲基-;N-乙基咪唑

SB431542

2-Methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile;2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile;BEZ235;2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phe...;2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-ylimidazo[4,5-c]quinolin-1-yl)phenyl]propanenitrile;Benzeneacetonitrile, 4-[2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-a,a-dimethyl-;Bez235 (nvp-bez235);BEZ235 (NVP-BEZ235, Dactolisib);NVP-BEZ 235;NVP-BEZ235 (BEZ235);2-methyl-2-[3-methyl-2-oxo-8-(3-quinolinyl)-1-imidazo[4,5-c]quinolinyl]propanenitrile;BEZ-235;Dactolisib;NVPBEZ235;BEZ 235;NVP BEZ235;RUJ6Z9Y0DT;JOGKUKXHTYWRGZ-UHFFFAOYSA-N;2-Methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile;2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihyd

301836-41-9

C₂₂H₁₆N₄O₃

384.39

SB-431542是TGF-β受体激酶抑制剂(TRKI)。SB-431542 对ALK4、ALK5和ALK7活性有抑制作用， IC50值分别为1 μM、0.75 μM和2 μM。SB-431542还能抑制TGF-β诱导的转录、基因表达、细胞凋亡和生长抑制。SB-431542可用于癌症及其信号转导途径的研究。