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Ceruletide

(Synonyms: 雨蛙素; Caerulein; Cerulein; FI-6934)

目录号: PC62834 纯度: ≥99%

Ceruletide 是一种十肽，也是一种有效的胆囊收缩素受体 (cholecystokinin receptor) 激动剂。 Ceruletide 是一种安全有效的胆囊收缩剂，对胆囊肌肉和胆管有直接的痉挛性作用。Ceruletide 是一种十肽，也是一种有效的胆囊收缩素受体 (cholecystokinin receptor) 激动剂。 Ceruletide 是一种安全有效的胆囊收缩剂，对胆囊肌肉和胆管有直接的痉挛性作用。

CAS No. :17650-98-5

商品编号	规格	价格	会员价	是否有货	数量
PC62834-500μg	500μg	¥2223.00	请登录
PC62834-1mg	1mg	询价	询价

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中文名称	Ceruletide
中文别名	雨蛙素;Caerulein 雨蛙素;硫酸化蓝肽;雨蛙素Caerulein;雨蛙肽;蓝肽
英文名称	Ceruletide
英文别名	Caerulein;CAERULEIN SULFATED;Caerulein, Ceruletide, Cerulein;caerulein 1.1;Ceosunin;CERULEIN;CERULETIDE;Ceruletide,Cerulein;FI-6934;sulfated caerulein;CAERULEIN 500 UG;[TYR(SO3H)4]CAERULEIN;Caerulein (~90%);Ceruletide, Cerulein;Ceruletidum;Ceruletida;Ceruletidum [INN-Latin];Ceruletida [INN-Spanish];Ceruletide [USAN:INN:BAN];Ceruletide diethylamine;5-Oxo-L-prolyl-L-glutaminyl-L-alpha-aspartyl-O-sulfo-L-tyrosyl-L-threonylglycyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide;5-Oxo-L-prolyl-L-glutaminyl-L-aspartyl-L-tyrosyl-L-threonylglycyl-L-tryptophyl-L-methionyl-L-aspartylphenyl-L-alaninamide 4-(hydrogen sulfate) (ester);888Y0
Cas No.	17650-98-5
分子式	C₅₈H₇₃N₁₃O₂₁S₂
分子量	1352.41
包装储存	sealed storage and away from moisture；Powder； -80°C； 2 years; -20°C； 1 year；
详情描述	Ceruletide 是一种十肽，也是一种有效的胆囊收缩素受体 (cholecystokinin receptor) 激动剂。 Ceruletide 是一种安全有效的胆囊收缩剂，对胆囊肌肉和胆管有直接的痉挛性作用。Ceruletide 是一种十肽，也是一种有效的胆囊收缩素受体 (cholecystokinin receptor) 激动剂。 Ceruletide 是一种安全有效的胆囊收缩剂，对胆囊肌肉和胆管有直接的痉挛性作用。

生物活性	Ceruletide is a decapeptide and a potent cholecystokinin receptor agonist. Ceruletide is a safe and effective cholecystokinetic agent with a direct spasmogenic effect on the gallbladder muscle and bile ducts.
性状	Solid
IC50 & Target[1][2]	Cholecystokinin receptor
体外研究(In Vitro)	Ceruletide is similar chemically and biologically to the human gastrointestinal hormones cholecystokinin-pancreozymin (CCK) and gastrin II. Ceruletide stimulates gallbladder contraction, pancreatic exocrine secretion, gastric secretion, and motility in the distal duodenum, jejunum, ileum and colon, while delaying gastric emptying and inhibiting motility in the proximal duodenum. Ceruletide in supramaximal but not in physiological doses activates NF-kappaB/Rel in vitro. This activation may induce a self-defending genetic program before the onset of cellular injury, which may prevent higher degrees of damage of pancreatic acinar cells after secretagogue hyperstimulation.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Ceruletide (0.4-0.5 mcg/kg, i.v.; 3-4 mcg/kg, s.c.) results in emesis and evacuation of the bowel in the intact conscious dog, and recovery is complete 15-30 min after i. v. administration and 2-4 hr after s.c. administration. Ceruletide (5-15 ng/kg, i.v.) shows a marked spasmogenic effect on the pylorus of rats. Ceruletide also reduces blood pressure in anesthetized dogs. Ceruletide serum bile acid (SBA) stimulation circumvents exogenous and endogenous influences associated with postprandial (PP) SBA stimulation. Ceruletide SBA stimulation may perform as well as PP SBA stimulation in dogs with portosystemic shunt (PSS) and be more sensitive for the detection of hepatic dysfunction in dogs with upper respiratory disease (URD).Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transport.
储存方式	sealed storage and away from moisture；Powder； -80°C； 2 years; -20°C； 1 year；
SequenceShortening	{pGlu}-QD-Y(SO3H)-TGWMDF-NH2
Sequence	{pGlu}-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2
结构分类	Alkaloids Indole
来源	the skin of a tropical frog

溶解度数据	体外研究: H₂O : ≥ 100 mg/mL(73.94 mM) DMSO : 83.33 mg/mL(61.62 mM;Need ultrasonic) *≥ means soluble, but saturation unknown.

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Ceruletide

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