Galanthamine hydrobromide|1953-04-4|(氢溴酸加兰他敏; Galantamine hydrobromide)-陌孚医药/Medlife

您当前的位置：

Galanthamine hydrobromide (Synonyms: 氢溴酸加兰他敏; Galantamine hydrobromide)

目录号: PC63051 纯度: 10mM*1mL in DMSO

CAS No. :1953-04-4

商品编号	规格	价格	会员价
PC63051-50mg	50mg	¥522.50	请登录
PC63051-100mg	100mg	¥807.50	请登录
PC63051-1mL	1mL	¥627.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Galanthamine hydrobromide
中文别名	氢溴酸加兰他敏;氢溴加兰他敏;Galantamine Hydrobromide 氢溴酸加兰他敏;加兰他敏氢溴酸盐;毛喉鞘蕊花;氢溴酸加兰他敏 Galantamine Hydrobromide;氢溴酸加兰他敏（左旋加兰他敏）;氢溴酸加兰他敏,对照品;氢溴酸加兰他敏标准品;氢溴加兰他敏,galanthamine hydrobromide;氢溴酸加兰他敏,氢溴加兰他敏;氢溴酸加兰它敏,英文名:Razadyne,Galantamine Hydrobromide;11-甲基-3-甲氧基-4a,5,9,10,11,12-六氢-6H-苯并呋喃[3a,3,2ef][2]苯并氮杂卓-6-醇氢溴酸盐
英文名称	Galanthamine hydrobromide
英文别名	galanthamine hydrobromide;galantamine hydrobromide;Galanthamine hydrobromide from Lycoris sp.;Galantamine Hydrobrmide;Galanthamine HBr;(-)-Galanthaminium bromide;[3H]-Galantamine hydrobromide;GALANTAMINE HBR;GALANTHAMIDE HYDROBROMIDE;Galanthamine (hydrobromide);GALANTHAMINE HYDROBROMIDUM;NIVALIN;NIVALIN,HBR;Reminyl;Razadyne;MJ4PTD2VVW;Nivaline (pharmaceutical);C17H22BrNO3;Lycoremine hydrobromide;Reminyl (TN);SMR000449267
Cas No.	1953-04-4
分子式	C₁₇H₂₂BrNO₃
分子量	368.27
包装储存	4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

生物活性

Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC₅₀ of 0.35 μM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α₃β₄, α₄β₂, α₆β₄ nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimers disease (AD).

性状

Solid

IC50 & Target[1][2]

IC50: 0.35 μM (AChE)

体外研究(In Vitro)

Galanthamine hydrobromide is 53-fold selectivity for AChE over butyrylcholinesterase.
Galanthamine hydrobromide (25-1000 μM) inhibits both Aβ 1-40 (50 μM) and Aβ 1-42 (50 μM) aggregation.
Galanthamine hydrobromide (25-1000 μM) protects against Aβ(1-40) and Aβ(1-42) toxicity in SH-SY5Y cells.
Galanthamine hydrobromide also dramatically reduces Aβ(1-40)-induced cellular apoptosis.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Galanthamine hydrobromide (1.25-2.5 mg/kg; i.p. ) reduces cognitive deficits in APP23 mice.
Galanthamine hydrobromide (10 mg/kg; i.g.) displays short elimination half-life of approximately 2 h in wild-type mice.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Mode

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

ClinicalTrial

结构分类

Alkaloids
Other A

来源

Plants
Amaryllida

溶解度数据	体外研究: H₂O : 16.67 mg/mL(45.27 mM;ultrasonic and warming and heat to 80°C) DMSO : 12.5 mg/mL(33.94 mM;ultrasonic and warming and heat to 60°C)

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation