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Nuciferine

(Synonyms: 荷叶碱)

目录号: PC62904 纯度: ≥99%

Nuciferine 是一种 5-HT2A，5-HT2C 和 5-HT2B 拮抗剂，IC50 分别为 478 nM，131 nM 和 1 μM；也是 5-HT7 的反向激动剂，IC50 为 150 nM。Nuciferine 是一种 5-HT2A，5-HT2C 和 5-HT2B 拮抗剂，IC50 分别为 478 nM，131 nM 和 1 μM；也是 5-HT7 的反向激动剂，IC50 为 150 nM。

CAS No. :475-83-2

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中文名称	Nuciferine
中文别名	荷叶碱;1,2-二甲氧基-6-甲基-5,6,6A,7-四氢-4H-二苯并[DE,G]喹啉;荷叶碱提取物;荷叶碱NUCIFERIN;荷叶碱(标准品);何叶碱;Nuciferine 荷叶碱标准品;板蓝根提取物;板蓝根提取物（10:1）;大青叶提取物;荷叶碱 Nuciferine;荷叶碱,Nuciferine,植物提取物,标准品,对照品;荷叶碱,板蓝根提取物;荷叶碱,荷叶提取物;荷叶碱对照品;荷叶提取物;荷叶提取物（荷叶碱）;可乐果提取物;纳米级荷叶提取物;分析对照品;(R)-1,2-二甲氧基-6-甲基-5,6,6a,7-四氢-4H-二苯并[de,g]喹啉;1,2-二甲氧基-6αβ-阿朴啡
英文名称	Nuciferine
英文别名	NUCIFERINE;(-)-nucipherine;(r)-1,2-dimethoxyaporphine;1,2-dimethoxy-6a-beta-aporphin;5,6,6a,7-tetrahydro-1,2-dimethoxy-6-methyl-g)quinolin(r)-4h-dibenzo(d;l-5,6-dimethoxyaporphine;l-nuciferine;nuciferin;4H-Dibenzo[de,g]quinoline,5,6,6a,7-tetrahydro-1,2-dimethoxy-6-methyl-, (6aR)-;nuciferina;R-(-)-nuciferine;Sanjoinine E;1,2-Dimethoxy-6αβ-aporphine;(R)-1,2-Dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline;1,2-Dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline;Lotus Leaf P.Extract.;1,2-Dimethoxy-6abeta-aporphine;W26UEB90B7;6a-beta-APORPHINE, 1,2-DIMETHOXY-;4H-Dibenzo(de,g)quinoline, 5,6,6a,7-tetrahydro-1,2-dimethoxy-6-methyl-, (R)-;(-)-nuciferine;(6ar)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinoline;1-5, 6-Dimethoxyaporphine;6a
Cas No.	475-83-2
分子式	C₁₉H₂₁NO₂
分子量	295.38
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；
详情描述	Nuciferine 是一种 5-HT2A，5-HT2C 和 5-HT2B 拮抗剂，IC50 分别为 478 nM，131 nM 和 1 μM；也是 5-HT7 的反向激动剂，IC50 为 150 nM。Nuciferine 是一种 5-HT2A，5-HT2C 和 5-HT2B 拮抗剂，IC50 分别为 478 nM，131 nM 和 1 μM；也是 5-HT7 的反向激动剂，IC50 为 150 nM。

生物活性	Nuciferine is an antagonist at 5-HT_2A (IC₅₀=478 nM), 5-HT_2C (IC₅₀=131 nM), and 5-HT_2B (IC₅₀=1 μM), an inverse agonist at 5-HT₇ (IC₅₀=150 nM), a partial agonist at D₂ (EC₅₀=64 nM), D₅ (EC₅₀=2.6 μM) and 5-HT₆ (EC₅₀=700 nM), an agonist at 5-HT_1A (EC₅₀=3.2 μM) and D₄ (EC₅₀=2 μM) receptor.
性状	Solid
IC50 & Target[1][2]	5-HT2C Receptor 131 nM (IC50)5-HT7 Receptor
体外研究(In Vitro)	Nuciferine is a partial agonist at DD2 receptor with an activity (Emax=67% of dopamine) similar to aripiprazole (Emax=50% of dopamine). In line with its partial agonist activity, Nuciferine inhibited dopamine-induced activation of Gi with a potency similar to clozapine (Nuciferine KB=62 nM; Clozapine KB=20 nM) as determined via Schild regression analysis. The natural product Nuciferine acts as an effective inhibitor of adult worm motility. Nuciferine is effective at inhibiting both basal and 5-HT evoked motility of adult schistosomes. Nuciferine inhibits Sm.5HTRL and schistosomule with 0.24±0.04 and 0.62±0.22 μM, respectively.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	In rodent models relevant to antipsychotic drug action, Nuciferine blocks head-twitch responses and discriminative stimulus effects of a 5-HT2A agonist, substituted for clozapine discriminative stimulus, enhanced amphetamine induced locomotor activity, inhibited phencyclidine (PCP)-induced locomotor activity, and rescued PCP-induced disruption of prepulse inhibition without induction of catalepsy. In the presence of 1 or 3 mg/kg Nuciferine, cumulative PCP doses produce similar substitution to PCP alone. In the clozapine-trained animals, a dose-dependent substitution for 1.25 mg/kg clozapine is seen at 10 mg/kg Nuciferine (80.63% drug lever responding), with an ED50 value of 5.42 mg/kg (95% CI 3.09-9.48 mg/kg) while the lower doses tested (0.1 mg/kg-3 mg/kg) fails to produce substitution for clozapine’s discriminative cue. In addition to a high percentage
运输条件	Room temperature or refrigerated transport.
储存方式	Powder； -20°C； 3 years; 4°C； 2 years；
结构分类	Alkaloids Isoquin
来源	Plants other fami

溶解度数据	体外研究: DMSO : 5 mg/mL(16.93 mM;ultrasonic and warming and heat to 60°C) 配制储存液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Nuciferine

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