Prodigiosin hydrochloride|56144-17-3|(Prodigiosine hydrochloride)-陌孚医药/Medlife

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Prodigiosin hydrochloride (Synonyms: Prodigiosine hydrochloride)

目录号: PC63096 纯度: ≥98%

CAS No. :56144-17-3

商品编号	规格	价格	会员价	是否有货	数量
PC63096-500μg	500μg	¥4631.00	请登录
PC63096-1mg	1mg	询价	询价

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中文名称	Prodigiosin hydrochloride
中文别名	盐酸灵菌红素
英文名称	Prodigiosin hydrochloride
英文别名	2,?2'-?Bi-?1H-?pyrrole, 4-?methoxy-?5-?[(5-?methyl-?4-?pentyl-?2H-?pyrrol-?2-?ylidene)?methyl]?-?, hydrochloride (1:1);2,2'-Bi-1H-pyrrole, 4-methoxy-5-[(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl]-, hydrochloride (1:1);2,2′-Bi-1H-Pyrrole,4-methoxy-5-[(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl;2-Methyl-3-amyl-6-methoxyprodigiosene;Prodigiosin hydrochloride;PRODIGIOSIN CHLORIDE;4-Methoxy-5-((5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl)-1H,1'H-2,2'-bipyrrole hydrochloride
Cas No.	56144-17-3
分子式	C₂₀H₂₆ClN₃O
分子量	359.89
包装储存	-20°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

生物活性	Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin hydrochloride is a potent proapoptotic agent, and inhibitsWnt/β-catenin pathway. Prodigiosin hydrochloride has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties.
性状	Solid
IC50 & Target[1][2]	Plasmodium

体外研究(In Vitro)

Prodigiosin (25-500 nM; 24 hours) treatment reduces the viability of breast cancer cells, with IC50 values at 48 h of 62.52 nM in MDA-MB-231 cells and 261.2 nM in MDA-MB-468 cells.
Prodigiosin (25-500 nM; 24 hours) treatment significantly reduces the levels of phosphorylated LRP6 and DVL2, active β-catenin, and total β-catenin. Prodigiosin noticeably inhibits the phosphorylation of GSK3β at Ser9 in HEK293T cells, which is indicative of an increase in GSK3β activity.
Prodigiosin can inhibit proliferation and induce apoptosis in breast cancer cells.
Prodigiosin (25-500 nM; 24 hours) treatment dose-dependently blocks Wnt signaling activated by Wnt1, Wnt3, Wnt1/LRP6, Wnt3/LRP6, and Dishevelled 2 (DVL2) in transfected HEK293T cells. Prodigiosin treatment inhibits Wnt3A-CM-induced transcription in a dose-dependent manner. Prodigiosin inhibits transcription of

体内研究(In Vivo)

Prodigiosin (5 mg/kg; intraperitoneal injection; twice weekly; for 3 weeks) treatment significantly inhibits tumor growth. Prodigiosin treatment decreases tumor cell density and expression of the proliferation marker Ki-67.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Animal

运输条件

Room temperature or refrigerated transport.

储存方式

-20°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

结构分类

Alkaloids
Pyrrole

来源

Serratia marcescens

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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