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| 中文名称 |
Nalidixic acid.
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|---|---|
| 中文别名 |
萘啶酸;萘啶酮酸;3-苄氧基-2.6-二氟苯硼酸;Nalidixic Acid 萘啶酸;Nalidixic acid 萘啶酮酸;WAKO144-06611萘啶酸标准品;奈啶酸;萘啶酸 EP标准品;萘啶酸 标准品;萘啶酮酸 USP标准品;萘啶酮酸(CN琼脂冻干配套试剂),0.2g,对多数革兰氏阴性细菌有抑制作用;1-乙基-7-甲基-4-酮-1,8-萘啶-3-羧酸;7-甲基-1-乙基-4-氧代-1,4-二氢-1,8-萘啶-3-羧酸;萘啶酸,1-乙基-7-甲基-4-酮-1,8-萘啶-3-羧酸;1,4-二氢-1-乙基-7-甲基-1,8-萘啶-4-酮-3-羧酸;1-乙基-1,4-二氢-7-甲基-4-氧代-1,8-萘啶-3-羧酸
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| 英文名称 |
Nalidixic acid
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| 英文别名 |
Nalidixic acid;1,4-Dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid;1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid;Cetrimide Nalidixic acid Agar Supplement;1-Ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid;5,5-Diphenylimidazolidine-2,4-dione;1,4-Dihydro-1-ethyl-7-Methyl-4-oxo-1,-naphthyridine-3-carboxylic acid;3-Carboxy-1-ethyl-7-Methyl-1,8-naphthyridin-4-;cybis;nalix;negram;NOGRAM;poleon;uriben;Urisal;uroman;uroneg;uropan;Nevigramon;Nalidixin;Uronidix;Nalidixate;Innoxalon;Nalitucsan;Nalidixan;Sicmylon;Unaserus;NegGram;Nalidic acid;Nalidixinic acid;Wintomylon;Nalurin;Naxuril;Jicsron;Dixinal;Dixiben;Acide nalidixique;Nalidicron;Specifin;Specifen;Nicelate;Narigix;Urodixin;Uriclar;Uralgin;Kusnarin;Betaxina;Naldixic acid;Acido nalidixico;Acidum nalidixicum;E;Eucistin;Acide nalidixico;Acido nalid
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| Cas No. |
389-08-2
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| 分子式 |
C12H12N2O3
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| 分子量 |
232.24
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| 包装储存 |
Powder； -20°C； 3 years; 4°C； 2 years；
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| 详情描述 |
Nalidixic acid，一种喹诺酮类抗生素 (antibiotic)，对革兰氏阳性和革兰氏阴性细菌均有效。Nalidixic acid 在较低浓度下以抑菌的方式起作用，而在较高浓度下具有杀菌作用。Nalidixic acid 抑制 DNA 促旋酶和拓扑异构酶 IV 的亚基，并可逆地阻止易感细菌中的 DNA 复制。Nalidixic acid，一种喹诺酮类抗生素 (antibiotic)，对革兰氏阳性和革兰氏阴性细菌均有效。Nalidixic acid 在较低浓度下以抑菌的方式起作用，而在较高浓度下具有杀菌作用。Nalidixic acid 抑制 DNA 促旋酶和拓扑异构酶 IV 的亚基，并可逆地阻止易感细菌中的 DNA 复制。 |
| 生物活性 |
Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria.
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|---|---|
| 性状 |
Solid
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| IC50 & Target[1][2] |
Quinolone Topoisomerase
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| 体外研究(In Vitro) |
Nalidixic acid is against a variety of microorganisms, it is against with Escherichia coli, Pasteurella spp., Klebsiella pneuiiioniae, Aerobacter aeroyenes, Proteus spp., Salmonella spp., Shigella spp. and Brucella spp. with MIC values of 5.0-12.5 μg/ml, 0.5-2.5 μg/ml, 0.8-25.0 μg/ml, 1.0-25.0 μg/ml, 1.25-30.0 μg/ml, 8-3.2 μg/ml, and 7.5-10.0 μg/ml, respectively.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
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| 体内研究(In Vivo) |
The in vivo activity of Nalidixic acid is most pronounced against Gram-negative bacteria, while Gram-positive organisms are generally more resistant. Maximal activity is observed against systemic infections caused by E. coli, A. aerobacter, Proteus mirabilis, Shigella fkxneri, the ED50 values are 25 mg/kg, 60 mg/kg, 50 mg/kg, and 62 mg/kg, respectively.The acute toxicity (LD50) of Nalidixic acid in mice following oral and parenteral administration is: oral, 3300 mg/kg; intravenous, 176 mg/kg, and subcutaneous, 500 mg/kg.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
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| 运输条件 |
Room temperature or refrigerated transport.
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| 储存方式 |
Powder； -20°C； 3 years; 4°C； 2 years；
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| 结构分类 |
AntibioticsOther
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| 来源 |
Streptomyces sp.
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| 溶解度数据 |
体外研究:DMSO : 6 mg/mL(25.84 mM;Need ultrasonic)H2O : 5 mg/mL(21.53 mM;ultrasonic and warming and heat to 80°C)配制储存液
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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