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(-)-Securinine

(Synonyms: 一叶秋碱)

目录号: PC62980 纯度: ≥99%

(-)-Securinine 是一种植物来源的生物碱，也是一种 GABAA 受体拮抗剂。(-)-Securinine 是一种植物来源的生物碱，也是一种 GABAA 受体拮抗剂。

CAS No. :5610-40-2

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中文名称	(-)-Securinine
中文别名	一叶萩碱;一叶秋碱;硝酸一叶秋碱;叶秋碱;一叶秋碱 ,一叶萩碱;叶底珠碱;一叶碱;一叶萩碱、一叶秋碱;5-羧基-N-苯基-2-1H-吡啶酮;一叶萩碱(一叶秋碱)
英文名称	(-)-Securinine
英文别名	securinine;SECURAN-11-ONE;(-)-securinin;securinan-11-one;securinin;Securinan-11-on;SECURININE(RG);(2β,7S,9S)-Securinan-11-one;8H-6,11b-Methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one,9,10,11,11a-tetrahydro-, (6S,11aR,11b...;8H-6,11b-Methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one,9,10,11,11a-tetrahydro-, (6S,11aR,11bS)-;1,2,3,4,10,10a-Hexahydro-10-hydroxy;Securan one;TNP00256;NE56622;(1S,2R,8R)-14-Oxa-7-azatetracyclo[6.6.1.0^{1,11}.0^{2,7}]pentadeca-9,11-dien-13-one;(-)-Securinine;Securinine, (-)-;G4VS580P5E;Virosecurinine;Viroallosecurinine;Securinina;Securininum;Securinine [INN];Securininum [INN-Latin];Se
Cas No.	5610-40-2
分子式	C₁₃H₁₅NO₂
分子量	217.26
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	(-)-Securinine is plant-derived alkaloid and also a GABA_A receptor antagonist.
性状	Solid
IC50 & Target[1][2]	GABAA receptor
体外研究(In Vitro)	(-)-Securinine is a major plant-derived alkaloid and also a GABAA receptor antagonist. (-)-Securinine is significantly potent on HeLa cells growth inhibition with IC50 values of 7.02±0.52 μg/mL (32.3 μM). (-)-Securinine induces apoptosis in a dose-dependent manner in the tested cells, increases the percentage of ROS positive cells and depolarized cells as well as stimulates the activity of ERK1/2, caspase-9 and -3/7. (-)-Securinine also induces cell cycle arrest in S phase. Real-time PCR analysis shows high expression of tumor necrosis factor receptor superfamily(TNFRSF) genes in the cells stimulated with (-)-Securinine.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	In this tumor model, tumor growth is significantly impaired with (-)-Securinine treatment indicating that (-)-Securinine has potential as an Acute Myeloid Leukemia (AML) therapeutic. (-)-Securinine treated mice (n=5 mice, bilateral tumors), exhibit an average of more than 75% smaller tumors than vehicle treated mice at the end of the study period.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transport.
储存方式	Powder； -20°C； 3 years; 4°C； 2 years；
结构分类	Alkaloids Pyridin
来源	Plants

溶解度数据	体外研究: DMSO : 2 mg/mL(9.21 mM;Need ultrasonic) 配制储存液

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(-)-Securinine

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