(-)-Huperzine A (Huperzine A)|102518-79-6|(石杉碱甲; Huperzine A)-陌孚医药/Medlife

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(-)-Huperzine A (Huperzine A) (Synonyms: 石杉碱甲; Huperzine A)

目录号: PC62899 纯度: 10mM*1mL in DMSO

CAS No. :102518-79-6

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中文名称	(-)-Huperzine A (Huperzine A)
中文别名	石杉碱甲;(5R,9R,11E)-5-氨基-11-乙叉基-5,6,9,10-四氢-7-甲基-5,9-甲撑环辛并(B)吡啶-2(1H)酮;石杉碱钾A;石山碱甲;石杉碱甲HUPERZINE-A;石杉碱甲(标准品);(-)-石杉碱甲;(-)-Huperzine A (HupA) 抑制剂;(-)石杉碱甲;千层塔提取物;石杉碱A;石杉碱-甲;石杉碱甲（(-)-Huperzine A）;石杉碱甲,Huperzine A,植物提取物,标准品,对照品;石杉碱甲、千层塔提取物 Huperzine Serrate Extract, Huperzine A;哈伯因;石杉碱甲((±)-石杉碱甲A,卷柏石松验,哈伯因);石杉碱甲,(-)-Huperzine A,分析标准品;石杉碱甲虱子草、矮杉树、虱婆药、救命王.;(5R,9R,E)-5-氨基-11-亚乙基-7-甲基-5,6,9,10-四氢-5,9-甲撑环辛并[b]吡啶-2(1H)-酮;杉碱甲;石杉碱甲提取物;千层塔提取物.石杉碱甲;石杉碱甲, 来源于蛇足石杉;半枝莲提取物
英文名称	(-)-Huperzine A (Huperzine A)
英文别名	(-)-Huperzine A;5r-(5-alpha,9-beta,11e))-ydro-7-methyl;5,9-methanocycloocta(b)pyridin-2(1h)-one,5-amino-11-ethylidene-5,6,9,10-tetrah;HUPERIZINE;(-)-HUPERZINE A FROM HUPERZIA SERRATA;HUP, [5R-(5a,911E)]-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2-(1H)-one, Selagine,;5,9-Methanocyclooctabpyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (5R,9R,11E)-;(−)-Huperzine A;(5R,9R,E)-5-Amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one;Huperzine A;Huperzine-A;Hyaluronic acid disaccharide ΔDiHA, sodium salt;Huperzia Serrate P.E.;(?)-Huperzine A;(?)-Selagine;(-)-Selagine;Selagine;[ "Selagine" ];Haboyin;Hupzine A;Kimpukan A;Isoselagine;Huperizine A;HUPERZINE A(P);Chinese Lobelia Herb Extract;HUPERZINE A 1%;(-)-huperazine A;HupA;Hup A;DSSTox_RID_81302;DSSTox_CID_26038;DSSTox_GSID_46038;Huperzine;HuperzineA;0111871I23;(-)-Huperzine-A;(+)-Huperzine A;(-)-Huperzine A (H
Cas No.	102518-79-6
分子式	C₁₅H₁₈N₂O
分子量	242.32
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性

(-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease.

性状

Solid

IC50 & Target[1][2]

AChE
NMDA Receptor

体外研究(In Vitro)

(-)-Huperzine A (1 μM; 2 hours) attenuates Aβ23-35 (20 μM)-induced neuronal injury.
(-)-Huperzine A (100 μM) reversibly inhibits the NMDA-induced current (IC50=126 μM) in whole-cell voltage-clamp recording in CA1 pyramidal neurons acutely dissociated from rat hippocampus.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

(-)-Huperzine A (0.1-0.2 mg/kg; i.p.; daily; for 12 days) can alleviate the cognitive dysfunction and neuronal degeneration induced by i.c.v. infusion of beta-amyloid protein-(1-40) in rats.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

ClinicalTrial

结构分类

Alkaloids
Pyridin

来源

Plants

溶解度数据	体外研究: DMSO : ≥ 100 mg/mL(412.68 mM) *≥ means soluble, but saturation unknown. 配制储存液

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Data Sheet

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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