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Shikonin

(Synonyms: 紫草素; C.I. 75535; Isoarnebin 4)

目录号: PC61454 纯度: ≥99%

Shikonin 是中草药紫草的主要成分。Shikonin 是一种有效的 TMEM16A 氯化物通道 (chloride channel) 抑制剂，IC50 为 6.5 μM。Shikonin 是一种特异的丙酮酸激酶 M2 (PKM2) 抑制剂，还可以抑制 TNF-α 和 NF-κB途径。Shikonin 通过抑制糖酵解降低外泌体 (exosome) 的分泌。Shikonin 抑制 AIM2炎性体活化。Shikonin 是中草药紫草的主要成分。Shikonin 是一种有效的 TMEM16A 氯化物通道 (chloride channel) 抑制剂，IC50 为 6.5 μM。Shikonin 是一种特异的丙酮酸激酶 M2 (PKM2) 抑制剂，还可以抑制 TNF-α 和 NF-κB途径。Shikonin 通过抑制糖酵解降低外泌体 (exosome) 的分泌。Shikonin 抑制 AIM2炎性体活化。

CAS No. :517-89-5

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PC61454-1mL	1mL	¥543.00	请登录

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中文名称	Shikonin
中文别名	紫草素;5,8-二羟基-2-[(1R)-1-羟基-4-甲基戊-3-烯基]萘-1,4-二酮;R-紫草素;右旋紫草素;紫草红;紫草素（右旋）;紫草素(左旋紫草素);紫草素, 来源于紫草;紫草素,Shikonin,植物提取物,标准品,对照品;紫草素标准液;紫草素对照品;紫根色素;左旋紫草素;WAKO198-13581紫草醌（旋光异构体混合物,约6:1）;欧紫草;紫草红色素;紫草素(紫草醌,紫草宁,欧根草,紫根色素,右旋紫草素,紫草红、紫朱草素,紫根素);紫草素（紫草醌,紫草宁,欧根草,紫根色素,左旋紫草素,紫草红、紫朱草素,紫根素）;紫朱草素;左旋紫草素（标准品）
英文名称	Shikonin
英文别名	(R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione;5,8-Dihydroxy-2-[(1R)-1-hydroxy-4-methyl-pent-3-enyl]naphthalene-1,4-dione;Shikonin;SHIKONIN(AS);C.I. 75535;Isoarnebin 4;[ "" ];(+)-Shikonin,Alkannin;(-)-Shikonin;Tokyo Violet;(+)-Shikonin;Shikonin S;5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-en-1-yl]-1,4-dihydronaphthalene-1,4-dione;(R)-(+)-Shikonin;(+)-5,8-Dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthoquinone;Shikonin,(S)
Cas No.	517-89-5
分子式	C₁₆H₁₆O₅
分子量	288.30
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；
详情描述	Shikonin 是中草药紫草的主要成分。Shikonin 是一种有效的 TMEM16A 氯化物通道 (chloride channel) 抑制剂，IC50 为 6.5 μM。Shikonin 是一种特异的丙酮酸激酶 M2 (PKM2) 抑制剂，还可以抑制 TNF-α 和 NF-κB途径。Shikonin 通过抑制糖酵解降低外泌体 (exosome) 的分泌。Shikonin 抑制 AIM2炎性体活化。Shikonin 是中草药紫草的主要成分。Shikonin 是一种有效的 TMEM16A 氯化物通道 (chloride channel) 抑制剂，IC50 为 6.5 μM。Shikonin 是一种特异的丙酮酸激酶 M2 (PKM2) 抑制剂，还可以抑制 TNF-α 和 NF-κB途径。Shikonin 通过抑制糖酵解降低外泌体 (exosome) 的分泌。Shikonin 抑制 AIM2炎性体活化。

生物活性	Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation.
性状	Solid
IC50 & Target[1][2]	TMEM16A chloride channel 6.5 μM (IC50)PKM2 &n
体外研究(In Vitro)	Shikonin is an inhibitor of TMEM16A chloride channel with an IC50 of 6.5 μM. Shikonin is also a specific inhibitor of PKM2 and can also inhibit tumor necrosis factor-α (TNF-α) and prevent activation of nuclear factor-κB (NF-κB) pathway. Shikonin at concentrations higher than 50 μM significantly inhibits ormal human keratinocytes (NHKs) viability, compare with that of control (P<0.05). Pretreatment with Shikonin for 2 h attenuates TNF-α-induced NF-κB p65 nuclear translocation. Treatments of Shikonin at 5 and 7.5 μM significantly inhibit the cell viability starting from 12 h and the inhibitory effects are presented in time-dependent patterns compare with the 0 h group in both cell lines. It is found that 5 μM Shikonin displays greater inhibition compare to 2.5 μM at the time points from 24 to 48 h.The invasiveness of U87 and U251 cells is significantly attenuated
体内研究(In Vivo)	Shikonin significantly inhibits the increase in IL-1β and TNF-α expression levels in the rat model of osteoarthritis, compare with those in the osteoarthritis group (P<0.01). The NF-κB protein expression level is significantly suppressed by Shikonin in the rat model of osteoarthritis, compare with that in the osteoarthritis group (P<0.01).The induction of the iNOS level is suppressed by treatment with Shikonin in the rat model of osteoarthritis, compare with that in the osteoarthritis group (P<0.01). The administration of Shikonin markedly weakens the up-regulation of COX-2 protein expression in the rat model of osteoarthritis, as compare with that in the osteoarthritis group (P<0.01). The elevation of caspase-3 activity is significantly reduced by Shikonin treatment in the rat model of osteoarthritis, compare with that in the osteoarthritis group (P<0.01). Th
运输条件	Room temperature or refrigerated transport.
储存方式	Powder； -20°C； 3 years; 4°C； 2 years；
结构分类	Quinones Naphthal
来源	Plants

溶解度数据	体外研究: DMSO : 25 mg/mL(86.72 mM;ultrasonic and warming and heat to 60°C) 配制储存液<

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Shikonin

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