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4,6-O-Ethylidene-α-D-glucose

(Synonyms: Ethylidene-glucose)

目录号: PC63952 纯度: ≥98.0%

4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose) 是一种葡萄糖衍生物，是竞争性的葡萄糖转运蛋白 1 (GLUT1) 面部结合部位抑制剂，对野生型 2-脱氧-D-葡萄糖转运的 Ki 值为 12 mM。4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose) 是一种葡萄糖衍生物，是竞争性的葡萄糖转运蛋白 1 (GLUT1) 面部结合部位抑制剂，对野生型 2-脱氧-D-葡萄糖转运的 Ki 值为 12 mM。

CAS No. :13224-99-2

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中文名称	4,6-O-Ethylidene-α-D-glucose
中文别名	4,6-亚乙基-alpha-D-葡萄糖;4,6-O-亚乙基-α-D-吡喃葡萄糖 ;4,6-O-Ethylidene-alpha-D-glucopyranose 4,6-O-亚乙基-α-D-吡喃葡萄糖;4,6-O-亚乙基-α-D-葡萄糖;4,6-O-亚乙基-α4,6-O-亚乙基-D-葡萄糖;4,6-亚乙基-α-D-葡萄糖;small>-吡喃葡萄糖;4 6 0-乙缩醛-D-葡萄糖;4,6-O-亚乙基-Α-D-葡糖;4,6-O-亚乙基-Α-D-吡喃葡糖
英文名称	4,6-O-Ethylidene-α-D-glucose
英文别名	(4aR,7R,8R,8aS)-2-Methylhexahydropyrano[3,2-d][1,3]dioxine-6,7,8-triol;(4AR,7R,8R,8aS)-2-Methylhexahydropyrano-[3,2-d][1,3]dioxine-6,7,8-triol;4,6-O-Ethylidene-D-glucopyranoside;4,6-O-Ethylidene-α-D-glucose;ETHYLIDENE-ALPHA-D-GLUCOPYRANOSIDE,4,6-O-(RG);(2R,4aR,6S,7R,8R,8aS)-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxine-6,7,8-triol;-D<;4,6-O-Ethylidene-alpha-D-glucose;4,6-O-Ethylidene-α-D-glucopyranose;4,6-O-Ethylidene α-D-glucopyranose;NSC 89726;Glucopyranose,4,6-O-ethylidene-, a-D- (8CI);Pyrano[3,2-d]-1,3-dioxin, a-D-glucopyranose deriv.;4,6-O-Ethylidene a-D-glucopyranose;ethylideneglucose;4,6-O-ethylidene-D-glucose;4,6-O-ETHYLIDENE-A-D-GLUCOSE;4,6-O-ETHYLIDENE-ALPHA-D-GLUCOPYRANOSE;4,6-0-ETHYLIDENE-alpha-D-GLUCOPYRANOSE;Ethylidene glucose;4,6-O-ETHYLIDENE-ALPHA-D-GLUCOSE 96+%;4,6-O-Ethylidene-D-glucopyranose;D-Glucopyranose, 4,6-O-ethylidene-;FCH3991549;AX8092919;(4aR,7R,8R,8aS)-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxine-6,7,8-triol
Cas No.	13224-99-2
分子式	C₈H₁₄O₆
分子量	206.19
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；
详情描述	4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose) 是一种葡萄糖衍生物，是竞争性的葡萄糖转运蛋白 1 (GLUT1) 面部结合部位抑制剂，对野生型 2-脱氧-D-葡萄糖转运的 Ki 值为 12 mM。4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose) 是一种葡萄糖衍生物，是竞争性的葡萄糖转运蛋白 1 (GLUT1) 面部结合部位抑制剂，对野生型 2-脱氧-D-葡萄糖转运的 Ki 值为 12 mM。

生物活性	4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose), a glucose derivative, is a competitive exofacial binding-site inhibitor on glucose transporter 1 (GLUT1) with a K_i of 12 mM for wild-type 2-deoxy-D-glucose transport.
性状	Solid
IC50 & Target[1][2]	GLUT1 Human Endogenous Metabolite
体外研究(In Vitro)	4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose) shows poor affinity for malarial hexose transporter (PfHT1; Ki>50 mM). 4,6-O-ethylidene-α-D-glucose inhibits wild-type transport with a Ki of approximately 12 mM, but this is increased to greater than 120 mM in the Gln282-Leu mutant. 4,6-O-ethylidene-α-D-glucose inhibits glucose exit competitively but its penetration into human red cells is unaffected by glucose in the medium. The potentiation of the development of FDNB inhibition by sugars in the incubating medium is absent when 4,6-O-ethylidene-α-D-glucose is used and there is a slight protective action. 4,6-O-ethylidene-α-D-glucose penetrates human red cells by simple diffusion supported by its penetration of guinea-pig red cells at similar rates, by the occurrence of osmotic haemolysis in isosmotic solutions which is unaffected by copper ions
运输条件	Room temperature or refrigerated transport.
储存方式	Powder； -20°C； 3 years; 4°C； 2 years；
结构分类	Saccharides

溶解度数据	体外研究: H₂O : 125 mg/mL(606.24 mM;Need ultrasonic) DMSO : 100 mg/mL(484.99 mM;Need ultrasonic) 配制储存液

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4,6-O-Ethylidene-α-D-glucose

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