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Pilocarpine Hydrochloride.

(Synonyms: 盐酸毛果芸香碱)

目录号: PC62820 纯度: ≥99%

Pilocarpine Hydrochloride 是一种有效的 M3 型毒蕈碱乙酰胆碱受体 (M3 muscarinic receptor) 激动剂。Pilocarpine Hydrochloride 是一种有效的 M3 型毒蕈碱乙酰胆碱受体 (M3 muscarinic receptor) 激动剂。

CAS No. :54-71-7

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PC62820-100mg	100mg	¥494.00	请登录
PC62820-500mg	500mg	¥1222.00	请登录

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中文名称	Pilocarpine Hydrochloride.
中文别名	盐酸毛果芸香碱;( )-毛果芸香碱盐酸盐;(+)-毛果芸香碱盐酸盐;毛果芸香碱;毛果芸香碱盐酸盐;匹鲁卡品盐酸盐;盐酸毛果芸香碱 USP标准品;盐酸毛果芸香碱标准品;盐酸匹罗卡品;盐酸匹罗卡品 EP标准品;(3S,4R)-4,5-二氢-3-乙基-4-(1-甲基-1H-咪唑-5-基甲基)-2(3H)-呋喃酮盐酸盐;氨噻唑;盐酸匹鲁卡品
英文名称	Pilocarpine Hydrochloride
英文别名	(+)-Pilocarpine hydrochloride;pilocarpine hcl;Pilocarpine Hydrochloride;(+)-Pilocarpine (hydrochloride);Pilocarpine (Hydrochloride);Pilocarpine Hydrochl;(3S,4R);(3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)-methyl]dihydrofuran-2(3H)one hydrochloride;Akarpine;ami-pilo;amisturap;pilocar;pilocarpine,2(3H)-furanone,3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)-methyl] monohydrochloride,(3S-cis);pilocel;pilovisc;Salagen;Sanpilo;(3S,4R)-4,5-Dihydro-3-ethyl-4-(1-methyl-1H-imidazol-5-ylmethyl)-2(3H)-furanone hydrochloride;Pilocarpal;Almocarpine;Pilocar SMP;Adsorbocarpine;Pilomiotin;Sno pilo;Mistura P;Pilocarpine muriate;Epicar;MI-Pilo Ophth Sol;Isopto-carpine;Isopto carpine;Amistura P;Pilocarpine, hydrochloride;Spersacarpine hydrochloride;Pilokarpin monohydrochloride;Pilocarpine monohydrochloride;PILOPINE HS;pilocarpine-hcl;Pilocarpine chloride;Pilopine HS Gel
Cas No.	54-71-7
分子式	C₁₁H₁₇ClN₂O₂
分子量	244.72
包装储存	4°C, sealed storage and away from moisture；*该产品在溶液状态不稳定，建议您现用现配，即刻使用。；

生物活性

Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

性状

Solid

IC50 & Target[1][2]

M3 muscarinic receptor

体外研究(In Vitro)

To evaluate the cytotoxicity of Pilocarpine, the morphology and viability of human corneal stromal (HCS) cells are examined by light microscopy and MTT assay, respectively. Morphological observations show that HCS cells exposed to Pilocarpine at a concentration from 0.625 to 20 g/L exhibit dose- and time-dependent proliferation retardation and morphological abnormality such as cellular shrinkage, cytoplasmic vacuolation, detachment from culture matrix, and eventually death, while no obvious difference is observed between those exposed to Pilocarpine below the concentration of 0.625 g/L and controls. Results of MTT assay reveal that the cell viability of HCS cells decrease with time and concentration after exposing to Pilocarpine above the concentration of 0.625 g/L (P<0.01 or 0.05), while that of HCS cells treated with Pilocarpine below the concentration of 0.625 g/L show n

体内研究(In Vivo)

The Pilocarpine-induced saliva secretion of the control rats (CN) and exercised (EX) rats is examined. A significantly greater amount of saliva is induced by Pilocarpine in the EX rats than in the CN rats (P<0.01). Conversely, the Na concentration in the saliva of the EX rats is significantly lower than that of the CN rats (P<0.05).Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, sealed storage and away from moisture；*该产品在溶液状态不稳定，建议您现用现配，即刻使用。；

ClinicalTrial

结构分类

Alkaloids
Other A

来源

Plants
other fami

溶解度数据	体外研究: DMSO : 100 mg/mL(408.63 mM;Need ultrasonic) H₂O : ≥ 37 mg/mL(151.19 mM) *≥ means soluble, but saturation unknown.

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Pilocarpine Hydrochloride.

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