Sulfosuccinimidyl Oleate (sodium salt)|1212012-37-7|(Sulfo-N-succinimidyl oleate sodium)-陌孚医药/Medlife

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Sulfosuccinimidyl Oleate (sodium salt) (Synonyms: Sulfo-N-succinimidyl oleate sodium)

目录号: PC18492 纯度: ≥95%

CAS No. :1212012-37-7

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中文名称	Sulfosuccinimidyl Oleate (sodium salt)
中文别名	9-octadecenoic acid, 2,5-dioxo-3-sulfo-1-pyrrolidinyl ester, monosodium salt
英文名称	Sulfosuccinimidyl Elaidate Sodium
英文别名	Sulfosuccinimidyl Elaidate Sodium;Sulfosuccinimidyl oleate sodium
Cas No.	1212012-37-7
分子式	C₂₂H₃₆NO₇S^.Na
分子量	482.60

生物活性	Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect[1][2].
性状	A crystalline solid
体外研究(In Vitro)	Sulfosuccinimidyl oleate (50 μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50 μM, 24 hours)[1].
体内研究(In Vivo)	In male BALB/cABom mice with pMCAo model, Sulfosuccinimidyl oleate (50 mg/kg; administered once by single oral gavage) significantly reduces the cortical ischemic infarct size compared to vehicle-treated controls. In addition, Sulfosuccinimidyl oleate(50 mg/kg) is suitable to see a beneficial effect after stroke[1].
运输条件	冷藏运输。
描述&特点	Sulfosuccinimidyl oleate sodium is a long-chain fatty acid that inhibits the transport of fatty acids to cells. Sulfosuccinimidyl oleate sodium is an effective, irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds to CD36 receptors on the surface of microglia.
参考文献	1. Dhungana H, et al. Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation. J Neuroinflammation. 2017 Dec 4;14(1):237 2. Drahota Z, et al. Succinimidyl oleate, established inhibitor of CD36/FAT translocase inhibits complex III of mitochondrial respiratory chain. Biochem Biophys Res Commun. 2010 Jan 15;391(3):1348-51.

溶解度数据	DMF: 25 mg/ml DMSO: 25 mg/ml

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