您当前的位置：

Propranolol HCl

(Synonyms: 盐酸普萘洛尔)

目录号: PC10707 纯度: ≥98%

竞争性和非选择性β-肾上腺素能受体抑制剂,Propranolol hydrochloride是一种非选择性β-肾上腺素能受体（βAR）拮抗剂, IC50 值为12 nM。

CAS No. :318-98-9

商品编号	规格	价格	会员价
PC10707-100mg	100mg	¥598.00	请登录
PC10707-500mg	500mg	¥853.00	请登录
PC10707-10mM (in 1mL DMSO)	10mM (in 1mL DMSO)	¥637.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Propranolol HCl
中文别名	心得安;萘心安;异丙基氨基-1-萘甲氧基-丙醇盐酸盐;盐酸普奈洛尔(心得安);1-异丙氨基-3-(1-萘氧基)-2-丙醇盐酸盐;盐酸普萘洛尔;(±)-盐酸普萘洛尔;盐酸普奈洛尔;(±)- 盐酸普萘洛尔标准品;DL-盐酸普萘洛尔;甲醇中心得安(普萘洛尔)溶液标准物质;消旋山莨菪碱;心得安,盐酸普萘洛尔[仅供出口];盐酸普奈洛尔标准品;盐酸普奈洛尔、盐酸普萘洛尔;盐酸普萘洛尔 EP标准品;盐酸普萘洛尔 USP标准品;盐酸普萘洛尔标准品;盐酸普萘洛尔,心得安;盐酸普萘洛尔性能测试 EP标准品;盐酸盐普萘洛尔标准品;心得安(普萘洛尔,Propranolol)盐酸盐标准品;盐酸普萘洛尔 1-异丙氨基-3-(1-萘氧基)-2-丙醇盐酸盐心得安;盐酸普萘洛尔,(±)-Propranolol hydrochloride;盐酸普莱洛尔;心得安,医药级,纯度:>99%;盐酸普萘若尔
英文名称	Propranolol HCl
英文别名	Propranolol Hydrochloride;(RS)-1-[(1-METHYLETHYL)AMINO]-3-(1-NAPHTHALENYLOXY)-2-PROPANOL HYDROCHLORIDE;PROPRANOLOL HCL;(+/-)-PROPRANOLOL HYDROCHLORIDE;(+/-)-PROPANOLOL HCL;PROPANOLOL HYDROCHLORIDE;1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanohydrochloride;1-(1-naphthyloxy)-2-hydroxy-3-isopropylaminopropanehydrochloride;(±)-Propranolol hydrochloride;1-(Isopropylamino)-3-(a-naphthoxy)-2-propanolhydrochloride;DL-Propranolol hydrochloride;Propranolol (hydrochloride);Propranolol hydrochloride solution;Propranolol hydrochloride(Ciplar®, Inderal®, Deralin®,Avlocardyl®);Propranolol Solution;rac-Propranolol Hydr;rac-Propranolol Hydrochloride;deralin;dociton;frekven;inderal;inderex;inderol;kemi;oposim;Propranolol;Propranolol hyd;tesnol;Propmnolol hydrochloride;(±)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride;DL-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride
Cas No.	318-98-9
分子式	C₁₆H₂₁NO₂^.HCl
分子量	295.80
包装储存	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	竞争性和非选择性β-肾上腺素能受体抑制剂,Propranolol hydrochloride是一种非选择性β-肾上腺素能受体（βAR）拮抗剂, IC50 值为12 nM。

生物活性

Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.

性状

Solid

IC50 & Target[1][2]

β adrenergic receptor

体外研究(In Vitro)

Propranolol hydrochloride (10 M-10 M; 24 and 48 hours) increases the total ERK1/2 levels in a dose-dependent manner, and ERK1/2 activation is observed specifically at 10 M in HemSCs.
Propranolol hydrochloride (10 M-10 M; 24 and 48 hours) significant decreases cell proliferation at 10 M propranolol after 24 hours and 10 M propranolol after 48 hours in HemSCs.
Propranolol hydrochloride (50 μM-200 μM; 24 hours) increases Annexin V positivity and caspase-3 activation, rapidly induces HemSC apoptosis.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	HemSC cells
Concentration:	10 M-10 M
Incubation Time:	24 and 48 hours
Result:	Increased the total ERK1/2 levels in a dose-dependent manner.

Cell Viability Assay

Cell Line:	HemSC cells
Concentration:	10 M-10 M
Incubation Time:	24 and 48 hours
Result:	Suppressed HemSC Proliferation.

Apoptosis Analysis

Cell Line:	HemSC cells
Concentration:	50 μM, 100 μM, or 200 μM
Incubation Time:	24 hours
Result:	Induced HemSC cell death occurred via an apoptotic pathway.

体内研究(In Vivo)

Propranolol hydrochloride (orally administration; 40 mg/kg; daily) significantly reduces the vessel diameter relative to the vehicle-treated implants, and increases the number of cells that expressed phosphorylated ERK1/2 within the IH Matrigel implant.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	A xenograft mouse model of IH (infantile hemangiomas) with HemSC cells
Dosage:	40 mg/kg
Administration:	Orally administration; 40 mg/kg; daily
Result:	Improved vessel development in the IH mouse model that correlated with MAPK pathway activation.

运输条件

Room temperature or refrigerated transportation.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

结构分类

参考文献

[1]. Galandrin S, et al. Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol. 2006 Nov;70(5):1575-84. Epub 2006 Aug 1 [Information]

[2]. Briley M, et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69(4):669-73. [Information]

[3]. Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338. [Information]

[4]. Munabi NC, et al. Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation. Stem Cells Transl Med. 2016 Jan;5(1):45-55. [Information]

溶解度数据

体外研究:

DMSO : ≥ 150 mg/mL (507.10 mM)

H₂O : 33.33 mg/mL (112.68 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.3807 mL	16.9033 mL	33.8066 mL
5 mM	0.6761 mL	3.3807 mL	6.7613 mL
10 mM	0.3381 mL	1.6903 mL	3.3807 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： PBS
Solubility: 25 mg/mL (84.52 mM); Clear solution; Need ultrasonic

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Propranolol HCl

相关产品

The molarity calculator equation

The dilution calculator equation