Glucosamine sulfate|29031-19-4|(硫酸氨基葡萄糖; D-Glucosamine sulfate)-陌孚医药/Medlife

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Glucosamine sulfate (Synonyms: 硫酸氨基葡萄糖; D-Glucosamine sulfate)

目录号: PC13982 纯度: ≥98%

CAS No. :29031-19-4

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中文名称	Glucosamine sulfate
中文别名	硫酸氨基葡萄糖;D-氨基葡萄糖硫酸钾盐;D-氨基葡糖硫酸酯;硫酸氨基葡萄糖(标准品);氨基葡萄糖硫酸盐;(2R,3R,4S,5R)-2-氨基-3,4,5,6-四羟基己醛;DC级氨基葡萄糖硫酸钾盐(载体HPMC);D-氨基葡萄糖硫酸盐;氨基葡萄糖硫酸盐,AR;氨基葡萄糖硫酸盐,CP;氨基葡萄糖硫酸盐.盐酸氨基葡萄糖.罗通定;硫酸氨基葡萄糖标准品;硫酸氨基葡萄糖Glucosamine sulfate;氨基葡萄糖硫酸钠盐;氨糖钠盐;硫酸氨基葡萄糖,氨基葡萄糖硫酸盐
英文名称	Glucosamine sulfate
英文别名	Glucosamine sulfate;2-Amino-2-deoxy-D-glucose sulfate;Glucosamine sulfate salt;D-GLUCOSAMINE SULFATE NACL;D-GLUCOSAMINE SULFATE POTASSIUM SALT;GLUCOSAMINE SULFATE POTASSIUM SALT, D-;Chitosamine Sulfate 2-Amino-2-deoxy-D-glucose XSulfate;D-Glucose, 2-amino-2-deoxy-, sulfate (salt);(2R,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal sulfate;D-GLUCOSAMINE SULFATE;D-Glucosamine Sulfate Salt;D-Glucosamine sulphate;GLUCOSAMINE SULFATE POTASSIUM CHLORIDE SALT(RG);Gevolox;Arthro;Glucosaminsulfat;Dona;(2R,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal xsulfate;Sulfato de glucosamina;glucosamine-sulfate;2-Amino-2-deoxy-D-glucose sulfate (salt);Glucosamine Sulfate 2KCL;Glucosamine Sulfate Na Salt;Glucosamine Sulfate DC 95%;C6H15NO9S;C6H13NO5.H2SO4;3915AB;s3850;P889;Sulfuric acid--2-amino-2-
Cas No.	29031-19-4
分子式	C₆H₁₅NO₉S
分子量	277.25
包装储存	Sealed and stored at 4℃，, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性

Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes.

性状

Solid

IC50 & Target[1][2]

Human Endogenous Metabolite

体外研究(In Vitro)

Glucosamine sulfate (D-Glucosamine sulfate) exhibits dose-dependent DPPH antioxidant activity.
Glucosamine sulfate treatment of Short-term (4 h) inhibits HIF-1α at the protein level, decreases phosphorylation of p70S6K and S6, translation-related proteins.
Glucosamine sulfate significantly decreases renal expression of α-smooth muscle actin, collagen I, and fibronectin in the obstructed kidneys and TGF-β1-treated renal cells.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

Sealed and stored at 4℃，, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

结构分类

Saccharides

参考文献

[1]. Bruyère O, et al. Efficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016 Feb;45(4 Suppl):S12-7. [Information]

[2]. Jamialahmadi K, et al. Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage. Environ Toxicol Pharmacol. 2014 Jul;38(1):212-9. [Information]

[3]. Jo JR, et al. Short-term treatment with glucosamine hydrochloride specifically downregulates hypoxia-inducible factor-1α at the protein level in YD-8 human tongue cancer cells. Int J Oncol. 2014 May;44(5):1699-706. [Information]

[4]. Park J, et al. Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling. J Mol Med (Berl). 2013 Nov;91(11):1273-84. [Information]

溶解度数据

体外研究:

H₂O : 125 mg/mL (450.86 mM; Need ultrasonic)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.6069 mL	18.0343 mL	36.0685 mL
5 mM	0.7214 mL	3.6069 mL	7.2137 mL
10 mM	0.3607 mL	1.8034 mL	3.6069 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： PBS
Solubility: 100 mg/mL (360.69 mM); Clear solution; Need ultrasonic

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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