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RepSox

(Synonyms: E-616452; SJN 2511)

目录号: PC15934 纯度: ≥98%

ALK5抑制剂，RepSox 是一种有效，选择性的 TGFβR-1/ALK5 抑制剂，抑制ALK5自磷酸化，IC50 为 4 nM。

CAS No. :446859-33-2

商品编号	规格	价格	会员价
PC15934-10mg	10mg	¥1146.00	请登录
PC15934-25mg	25mg	¥2102.00	请登录
PC15934-10mM (in 1mL DMSO)	10mM (in 1mL DMSO)	¥637.00	请登录

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中文名称	RepSox
中文别名	2-(3-(6-甲基吡啶-2-基)-1H-吡唑-4-基)-1,5-萘啶;2-[3-(6-甲基-2-吡啶基)-1H-吡唑-4-基]-1,5-萘啶;2-3-(6-甲基-2-吡啶基)-1H-吡唑-4-基-1,5-萘;ALK5抑制剂;ALK5抑制剂【TGF-β RI激酶抑制剂Ⅱ】;Alk-5抑制剂II;ALK5 INHIBITOR
英文名称	RepSox
英文别名	ALK5 INHIBITOR;2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine;RepSox;Alk 5 Inhibitor II;1vjy;E616452;E-616452;GW786460X;SJN 2511;SJN-2511;2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine;ALK5 Inhibitor II;TGF-beta RI Kinase Inhibitor II;C17H13N5;2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine;Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor II;2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine;2-(5-(6-methylpyridin-2-yl)-1H-pyraz
Cas No.	446859-33-2
分子式	C₁₇H₁₃N₅
分子量	287.32
包装储存	-20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
详情描述	ALK5抑制剂，RepSox 是一种有效，选择性的 TGFβR-1/ALK5 抑制剂，抑制ALK5自磷酸化，IC50 为 4 nM。

生物活性	RepSox (E-616452) (GMP) is a RepSox (HY-13012) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. RepSox is a potent and selective TGF-β-RI/ALK5 inhibitor.
性状	Solid
IC50 & Target[1][2]	IC50: ALK5 autophosphorylation (4 nM)
体外研究(In Vitro)	RepSox (GMP) (10 μM) induces MEFs differentiating to chemically induced pluripotent stem cells (CiPSCs). RepSox (GMP) (10 μM, in stage I-Stage III induction medium) induces hCiPS cells from HEFs. RepSox (GMP) together with Forskolin (HY-15371) increases the number of proliferative cells in MEFs expressing MyoD, confirmed by increased EdU incorporation. Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transportation.
储存方式	-20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Zhao T, et al. Single-Cell RNA-Seq Reveals Dynamic Early Embryonic-like Programs during Chemical Reprogramming. Cell Stem Cell. 2018 Jul 5;23(1):31-45.e7. [Information] [2]. Guan J, et al. Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature. 2022 May;605(7909):325-331. [Information] [3]. Bar-Nur O, et al. Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors. Stem Cell Reports. 2018 May 8;10(5):1505-1521. [Information]

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RepSox

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