PPQ-102 (0, 0.5, 5μM, 4 days) prevents and reverses renal cyst expansion in an embryonic kidney organ culture model of PKD.
PPQ-102 (0, 0.5, 5μM, 3 days) shows ability of reducing fluid accumulation in preformed cysts.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay
Cell Line: |
E13.5 embryonic kidneys (embryonic kidney organ culture model of PKD) |
Concentration: |
0, 0.5, 5 μM |
Incubation Time: |
3 or 4 days |
Result: |
Remarkablyreduced the number and size of renal cysts formed in the 8-Br-cAMP-containing medium (showed ~60% inhibition of cyst formation at 0.5 μM, near complete absence of cysts at 2.5 and 5 μM).
Remarkable reduced cyst size over 1 and 2 days in the 8-Br-cAMP-containing medium.
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