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CNQX disodium salt

AMPA/红藻氨酸受体拮抗剂,CNQX disodium (FG9065 disodium) 是一种有效的竞争性 AMPA /海藻酸酯受体 (AMPA/kainate receptor) 拮抗剂，IC50 分别为 0.3 μM 和 1.5 μM。CNQX disodium 是一种竞争性的非 NMDA 受体拮抗剂。CNQX disodium 会阻止大鼠恐惧增强的表达。

目录号: PC12156 纯度: ≥98%

CAS No. :479347-85-8

商品编号	规格	价格	会员价	是否有货	数量
PC12156-10mg	10mg	¥725.20	请登录
PC12156-50mg	50mg	¥2048.20	请登录

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中文名称	CNQX disodium salt
中文别名	CNQX disodium salt
英文名称	CNQX disodium salt
英文别名	CNQX disodium salt
Cas No.	479347-85-8
分子式	C₉H₂N₄Na₂O₄
分子量	276.12
包装储存	Sealed and stored at 4℃，, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性

CNQX disodium (FG9065 disodium) is a potent and competitive AMPA/kainate receptor antagonist with IC₅₀s of 0.3 μM and 1.5 μM, respectively. CNQX disodium is a competitive non-NMDA receptor antagonist. CNQX disodium blocks the expression of fear-potentiated startle in rats.

性状

Solid

IC50 & Target[1][2]

IC50: 0.3 μM (AMPA) and 1.5 μM (kainate receptor)

体外研究(In Vitro)

CNQX disodium (FG9065 disodium; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices.
CNQX disodium (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

CNQX disodium (FG9065 disodium; 0.75-3 mg/kg; IP; 20 min before testing) decreased the number of cocaine responses in a dose-dependent manner during the first 15-min cocaine-free interval.
The bilateral infusion of CNQX disodium (0.5 or 1.25 μg) into the amygdala or dorsal hippocampus 10 min prior to a retention test partially blocks the expression of stepdown inhibitory avoidance in rats 24 h after training. CNQX disodium causes a complete blockade at a dose of 0.5 μg.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats weighing 180-200 g
Dosage:	0.75, 1.5, and 3 mg/kg
Administration:	IP; 20 min before testing
Result:	Decreased the number of cocaine (IV; 0.25 mg/infusion) responses in a dose-dependent manner during the first 15-min cocaine-free interval.

运输条件

Room temperature or refrigerated transportation.

储存方式

Sealed and stored at 4℃，, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献

[1]. T Honoré, et al. Quinoxalinediones: Potent Competitive non-NMDA Glutamate Receptor Antagonists. Science. 1988 Aug 5;241(4866):701-3. [Information]

[2]. Neuman RS, et al. Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione(CNQX) in the hippocampus 体外研究. Neurosci Lett. 1988 Sep 23;92(1):64-8. [Information]

[3]. Alford S, et al. CNQX and DNQX block non-NMDA synaptic transmission but not NMDA-evoked locomotion in lamprey spinal cord. Brain Res. 1990 Jan 8;506(2):297-302. [Information]

[4]. Pia B?ckstr?m, et al. Attenuation of Cocaine-Seeking Behaviour by the AMPA/kainate Receptor Antagonist CNQX in Rats. Psychopharmacology (Berl). 2003 Feb;166(1):69-76. [Information]

[5]. Kim M, et al. Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear-potentiated startle. Behav Neural Biol. 1993 Jan;59(1):5-8. [Information]

溶解度数据

体外研究:

DMSO : 10.53 mg/mL (38.14 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 70°C)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.6216 mL	18.1081 mL	36.2161 mL
5 mM	0.7243 mL	3.6216 mL	7.2432 mL
10 mM	0.3622 mL	1.8108 mL	3.6216 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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