Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenaline transporter (NET), with a K_d of 0.76 nM. Nisoxetine hydrochloride is an antidepressant and local anesthetic, it can block voltage-gated sodium channels.

Solid

Kd: 0.76 nM (NET)

Nisoxetine hydrochloride 抑制 [H]Nisoxetine 与大鼠额叶皮层膜的结合，K_i 为 1.4±0.1 nM。
Nisoxetine hydrochloride 抑制[H]去甲肾上腺素摄取到大鼠额叶皮质突触体中，K_i 为 2.1±0.3 nM。
Nisoxetine hydrochloride 抑制 Na 电流，膜电位为 -70 和 -100 mV 时的 IC₅₀ 分别为 1.6 和 28.6 μM。

Nisoxetine (2.2 μM；单次鞘内注射) hydrochloride 显示出 100%、100% 和 100% 的运动功能、本体感觉阻滞，作用持续时间分别约为 61、96 和 236 分钟。
Nisoxetine (3,10, 30 mg/kg, i.p.) hydrochloride 抑制大鼠的再喂养反应 (摄入标准食物)。

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature or refrigerated transportation.

• [1]. Bé?que JC, et, al. Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters. Eur J Pharmacol. 1998 May 15; 349(1): 129-32.  [Information]

  [2]. Cheetham SC, et, al. [3H]nisoxetine-a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology. 1996 Jan; 35(1): 63-70.  [Information]

  [3]. Leung YM, et, al. Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats. Pharmacol Rep. 2013; 65(2): 350-7.  [Information]

  [4]. Bello NT, et al. High-fat diet-induced alterations in the feeding suppression of low-dose nisoxetine, a selective norepinephrine reuptake inhibitor. J Obes. 2013;2013:457047.  [Information]

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。