3902-71-4|Trioxsalen，≥98%|Medlife|Medlife为MCE，Selleck，麦克林，阿拉丁试剂，罗恩试剂，Sigma，安耐吉试剂，泰坦等同类产品品牌，上海现货，高性价比小分子化合物

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Trioxsalen

Trioxsalen是呋喃和补骨脂素衍生物, 与UV-A联用光疗治疗白癜风和手部湿疹, 光敏后产生交联DNA, 这可能会导致细胞程序性死亡。

目录号: PC10400 纯度: ≥98%

CAS No. :3902-71-4

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中文名称

Trioxsalen

中文别名

三甲沙林;4,5',8-三甲基补骨脂素;2,5,9-三甲基-7H-呋喃并[3,2-g][1]苯并吡喃-7-酮;4,5‘,8-三甲基]补骨脂素;Trioxsalen 三甲沙林;三甲基补骨脂素 USP标准品;三甲沙仑;2,5,9-三甲基呋[3,2-g]苯并吡喃-7-酮;4,5‘,8-三甲基补骨脂素;4,5’,8-三甲基补骨脂素;三甲补骨脂内酯;三甲补骨脂素;4,5′,8-三甲基补骨脂素

英文名称

Trioxsalen

英文别名

Trioxsalen;4,5',8-Trimethylpsoralen;2,5,9-trimethylfuro[3,2-g]chromen-7-one;TRIOXSALEN(RG);TRIOXSALEN(RG) PrintBack;Trioxysalen;2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one;2,5,9-Trimethylfuro[3,2-g]benzopyran-7-one;4,2',8-trimethylpsoralen;4,5‘,8-Trimethylpsoralen;4,5′,8-Trimethylpsoralen;Elder 8011;TMP;Trimethylpsoralen;Trioxisaleno;Trioxysalene;Trioxysalenum;Trisoralen;2',4,8-Trimethylpsoralen;4,5',8-Trimethylpsoralene;Trioxysalene [INN-French];Trioxysalenum [INN-Latin];NSC71047;Trioxisaleno [INN-Spanish];7H-Furo[3,2-g][1]benzopyran-7-one, 2,5,9-trimethyl-;TRIOXSALIN;4,8,5'-;4,8,5'-Trimethylpsoralen;2,5,9-Trimethyl

Cas No.

3902-71-4

分子式

C₁₄H₁₂O₃

分子量

228.24

包装储存

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

Trioxsalen (Trisoralen), a psoralen derivative, is a photochemical DNA crosslinker. Trioxsalen only works after photoactivation with near ultraviolet light. Trioxsalen is a photosensitizer that can be used for the research of vitiligo and hand eczema. Trioxsalen is used for visualization of genomic interstrand cross-links localized by laser photoactivation.

性状

Solid

体外研究(In Vitro)

Trioxsalen (200 nM) plus 365 nm light produce DNA crosslinks but not breaks in mouse L1210 leukemia cells.
Trioxsalen/UVA treatment of HaCaT keratinocytes induces NF-kappaB binding activity, and that this is a synergistic effect.
Trioxsalen shows anti-inflammatory capacities 体外研究.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Trioxsalen induces dose-dependent depletion of ATPase-positive LCs, with a maximal depletion of 80%, in oral mucous membrane (OMM) with PUVA (UVA doses of 1-8 J/cm2) in rat.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

[1]. M T Chuan, et al. Effectiveness of psoralen photochemotherapy for vitiligo. J Formos Med Assoc. 1999 May;98(5):335-40. [Information]

[2]. A Marco van Coevorden, et al. Comparison of oral psoralen-UV-A with a portable tanning unit at home vs hospital-administered bath psoralen-UV-A in patients with chronic hand eczema: an open-label randomized controlled trial of efficacy. Arch Dermatol. 200 [Information]

[3]. A Kuusilehto, et al. The effect of PUVA on langerhans cells in rat oral epithelium photosensitized with systemic methoxsalen or topical trioxsalen. Photodermatol Photoimmunol Photomed. 2000 Jun;16(3):129-33. [Information]

[4]. L F Cohen, et al. Interstrand DNA crosslinking by 4,58-trimethylpsoralen plus monochromatic ultraviolet light. Studies by alkaline elution in mouse L1210 leukemia cells. Biochim Biophys Acta. 1980 Nov 14;610(1):56-63. [Information]

[5]. H Sánchez Ruderisch, et al. Trioxsalen in the presence of UVA is able to induce nuclear factor kappa B binding activity in HaCaT keratinocytes. Skin Pharmacol Appl Skin Physiol. Sep-Oct 2002;15(5):335-41. [Information]

溶解度数据

体外研究:

DMSO : 6.6 mg/mL (28.92 mM; Need ultrasonic and warming)

H₂O : 1 mg/mL (4.38 mM; ultrasonic and warming and heat to 80°C)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.3814 mL	21.9068 mL	43.8135 mL
5 mM	0.8763 mL	4.3814 mL	8.7627 mL
10 mM	0.4381 mL	2.1907 mL	4.3814 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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