Benzenesulfonamide,2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]-;2,4,6-Trimethyl-N-(M-3-Trifluoromethyl)Phenyl)Benzenesulfonamide;2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide;M-3m3fbs;N-(3-Trifluoromethylphenyl)-2,4,6-trimethylbenzenesulfonamide;Phospholipase C Activator,m-3M3FBS;Tocris-1941
Cas No.
200933-14-8
分子式
C16H16NO2F3S
分子量
343.36
包装储存
Powder
-20°C
3 years
4°C
2 years
In solvent
-80°C
6 months
-20°C
1 month
生物活性
m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis.
性状
Solid
体外研究(In Vitro)
m-3M3FBS (5-50 μM) stimulates the formation of inositol phosphates in U937 cells.
m-3M3FBS (50 μM; 24 hours) inhibits the growth of the leukemic cell lines U937 and THP-1, but not primary monocytes.
m-3M3FBS (50 μM; 24 hours) induces U937 cell apoptosis.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay
Cell Line:
U937 and THP-1 cells
Concentration:
50 μM
Incubation Time:
24 hours
Result:
Inhibited the growth of the leukemic cell lines U937 and THP-1, but not primary monocytes.
Cell Viability Assay
Cell Line:
U937 cells
Concentration:
50 μM
Incubation Time:
24 hours
Result:
The apoptotic rate of m-3M3FBS-treated cells was 53.9%.